Trial reportObesity (Silver Spring, Md.)2026
Prospective Association Between Weight Variability and Subsequent Long-Term Weight Loss in the CALERIE Study.
Trial report in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00427193 (Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigher short-term weight variability (WV) predicts greater subsequent weight gain in weight-stable adults and toddlers and lower long-term weight loss among adults with overweight or obesity who previously lost weight. We extend prior work by examining the impact of naturally occurring WV on subsequent weight loss (weight at month 3 minus later weights) in individuals without obesity enrolled in the Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy (CALERIE) study.
methodsParticipants (N = 143) followed a 25% caloric restriction diet over 2 years. WV was calculated as the root-mean-squared-error of individuals' weights over the first 12 weeks. Multilevel models examined WV's prediction of subsequent weight loss at 6, 12, 18, and 24 months relative to month 3, adjusting for baseline BMI, 12-week weight change, and demographic variables. Sensitivity analyses further included time-varying adherence and eating behaviors (disinhibition, restraint, craving).
resultsHigher WV was associated with less subsequent weight loss at 6 months (B = -0.38, 95% CI [-0.63, -0.13], β = -0.16, p = 0.003). The interaction between time and WV was not significant; analyses suggested the association extends through year 1.
conclusionsShort-term WV predicted lower subsequent weight loss in adults without obesity. Once its biobehavioral mechanisms are understood, WV might provide insight into humans' innate capacity for long-term weight stability and inform future mechanistic research and clinical interventions.
trial registrationClinicalTrials.gov registration: NCT00427193.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.