ArticlePsychiatry investigation2026
Risks and Familial Coaggregation of Autism Spectrum Disorder Among First-Degree Relatives of Individuals With Colorectal Cancer.
Article in Psychiatry investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveAssociations between major mental disorders (MMDs) and colorectal cancer (CRC) have been reported; however, it remains unknown whether this association extends to an individual's kinship. The aim of this study was to explore the risks of MMDs in first-degree relatives (FDRs) of individuals with CRC.
methodsWe used data from the Taiwan National Health Insurance Research Database. FDRs of individuals with CRC were identified as the index group, and a demographic-matched group was also included as the controls. The primary outcome was the risk of an MMD. A Poisson regression model with robust error variance was used to estimate the relative risks and 95% confidence intervals.
resultsA total of 68,965 FDRs of individuals with CRC (38,024 males and 30,941 females) and 275,860 matched controls were included. After adjustments for potential confounders, the FDR-CRC group had a higher risk of autism spectrum disorder than the controls, especially in the males of fathers with CRC. In addition, individuals who had a son with CRC had a higher risk of bipolar disorder than the controls, especially females. Males whose mother had CRC had higher risks of attention deficit hyperactivity disorder and general anxiety disorder than the controls.
conclusionWith the unique association identified in this study between FDRs of individuals with CRC and the risk of MMDs, genetic studies are encouraged to explore the complicated etiologies behind this association.
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