Evidence map›Paper›PMID 42316301›Full record

ArticleActa neuropathologica communications2026

Intrathecal (G

Katelyn A Russell, Amelia A Shahrabi, Suleyman C Akerman, Matthew D Byrne, Jeffrey D Rothstein, Davide Trotti, Brigid K Jensen, Aaron R Haeusler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Katelyn A RussellDepartment of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Amelia A ShahrabiDepartment of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Suleyman C AkermanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Matthew D ByrneDepartment of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Jeffrey D RothsteinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Davide TrottiDepartment of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Brigid K JensenDepartment of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Aaron R HaeuslerDepartment of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA, 19107, USA. aaron.haeusler@jefferson.edu.

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Claudio Guillermo Giraudo · 1995 to 2026
$94.8M
The pathogenic relationship between neuronal activity and C9orf72-linked neurodegenerationRF1NS114128 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2020 to 2021
$2.5M
Contribution of astrocytes to mutant FUS-linked Amyotrophic Lateral SclerosisR01NS109150 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI PASINELLI, PIERA · 2019 to 2023
$1.7M
The pathogenic relationship between neuronal activity and C9orf72-linked neurodegenerationR01NS114128 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI HAEUSLER, AARON RAYMOND · 2024 to 2024
$537k
NCI NIH HHS P30 CA056036NINDS NIH HHS R01 NS109150NINDS NIH HHS R01NS109150NINDS NIH HHS R01 NS114128NINDS NIH HHS RF1 NS114128NINDS NIH HHS RF1NS114128
6 · The paper itself

Abstract

A repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet existing mouse models incompletely engage spinal regions implicated in disease. Here, an adeno-associated virus encoding (G

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaAnimalsDependovirusDisease Models, AnimalDNA-Binding ProteinsDNA Repeat ExpansionHumansInjections, SpinalMaleMiceMice, Inbred C57BLMice, TransgenicMotor NeuronsSpinal CordC9orf72 ProteinC9orf72 protein, mouseDNA-Binding ProteinsALSALS/FTDC9orf72C9orf72 repeat expansionsFTDMotor neuron diseaseMouse modelsNeurodegenerative disease

Identifiers

PMID42316301
PMCPMC13476920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.