ArticleVirology journal2026
Large-scale gastroenteritis outbreaks occurring in a university town of Guangzhou city during the global wave of the norovirus in China.
Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multi-database pharmacovigilance identifies disproportionate reporting of hepatobiliary events with avacopan: an integrative study with network pharmacology and interpretable machine learning.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noroviruses are the primary viral pathogens responsible for epidemic acute gastroenteritis. The novel GII.4 Sydney 2012 variant, which emerged during the 2012/13 winter season, led to significant global outbreaks. This study reports large-scale outbreaks occurring in the university town of Guangzhou, China, from January 8 to April 3, 2013. These outbreaks affected 652 individuals across five universities and one middle school. Of the 386 samples tested, 114 were norovirus-positive, and 19 stool or swab samples were genotyped as the GII.4 Sydney 2012 strain. The genome sequence of the GII.4 Sydney 2012 variant, GZ3135, was determined and compared with those of earlier GII.4 variants. This comparison revealed residue substitutions at specific sites, including the HBGA binding pocket and putative antigenic epitopes. The investigation outcomes showed that GII.4 Sydney variant infected individuals with both secretor and nonsecretor phenotypes. This finding was consistent with the HBGA binding results that the recombinant P protein of the GII.4 Sydney variant bound to saliva samples of nonsecretors, as well as the Lewis x and Lewis a oligosaccharides. Taken together, our data suggested that the GII.4 Sydney 2012 variant gained new HBGA binding ability and antigenic features which may contribute to its widespread epidemics.
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