Evidence map›Paper›PMID 42316268›Full record

ArticleChinese medicine2026

Critical role of high-dose Astragalus in Buyang Huanwu Decoction for enhancing neurovascular coupling in a Qi Deficiency and Blood Stasis animal model.

Kaichao Hu, Juxiang Yang, Guining Wei, Yaxian Zhao, Shifeng Chu, Liqing Li, Shasha Wang, Shanhe Qu, Lixiang Chen, Yuxin Zhang and 4 more

Abstract read
In one paragraph

Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kaichao Hu *College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130012, Jilin, China.
Juxiang Yang *Shanxi Key Laboratory of Integrative Systemic Regulation for Qi-Blood Homeostasis, National International Joint Research Center for Molecular Chinese Medicine, Shanxi University of Chinese Medicine, Taiyuan, 030024, China.
Guining Wei *Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, 530022, China.
Yaxian ZhaoShanxi Key Laboratory of Integrative Systemic Regulation for Qi-Blood Homeostasis, National International Joint Research Center for Molecular Chinese Medicine, Shanxi University of Chinese Medicine, Taiyuan, 030024, China.
Shifeng ChuState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Liqing LiState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Shasha WangState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Shanhe QuState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Lixiang ChenState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Yuxin ZhangState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Xu YanState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Zhao ZhangShanxi Key Laboratory of Integrative Systemic Regulation for Qi-Blood Homeostasis, National International Joint Research Center for Molecular Chinese Medicine, Shanxi University of Chinese Medicine, Taiyuan, 030024, China. zhangzhao@imm.ac.cn.
Naihong ChenCollege of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130012, Jilin, China. chennh@imm.ac.cn.
Wenbin HeShanxi Key Laboratory of Integrative Systemic Regulation for Qi-Blood Homeostasis, National International Joint Research Center for Molecular Chinese Medicine, Shanxi University of Chinese Medicine, Taiyuan, 030024, China. hewb@sxtcm.edu.cn.

Funding

Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Guangxi Institute of Chinese Medicine & Pharmaceutical Science 2202402National Natural Science Foundation of China U21A20410
6 · The paper itself

Abstract

backgroundBuyang Huanwu Decoction (BHD) is a classical Traditional Chinese Medicine (TCM) formula effective for treating Chronic Cerebral Ischemia with Qi Deficiency and Blood Stasis Syndrome (CCI

objectiveThis study aimed to compare the therapeutic efficacy of BHD with a high dose of Astragalus (120 g, BHD

methodsA mouse model of CCI

resultsBHD

conclusionOur findings demonstrate that the high dose of Astragalus is essential for the therapeutic efficacy of BHD under the conditions of the present experimental model. BHD

Indexed as

Buyang Huanwu DecoctionHigh-dose AstragalusNeurovascular couplingNeurovascular unitQi Deficiency and Blood Stasis Syndrome

Identifiers

PMID42316268
PMCPMC13277118

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