Evidence map›Paper›PMID 42316121›Full record

ArticleBMC ophthalmology2026

The role of DNMT3B, GSK-3β and GJA3 in lens epithelial cell apoptosis and age-related cataract.

Xiaoya Chen, Dongmei Su, Gaobo Zhang, Zihan Xiang, Yanjiang Fu, Zhaoyi Sun, Yuzhu Hu, Sijia Li, Yue Zhang, Xu Ma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoya Chen *Mudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China.
Dongmei Su *Department of Genetics, Health Department, National Research Institute for Family Planning, Beijing, 100081, China.
Gaobo ZhangMudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China.
Zihan XiangMudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China.
Yanjiang FuDaqing Ophthalmology Hospital, Daqing, Heilongjiang, 163711, China.
Zhaoyi SunHongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China.
Yuzhu HuMudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China.
Sijia LiHongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China.
Yue ZhangMudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China.
Xu MaDepartment of Genetics, Health Department, National Research Institute for Family Planning, Beijing, 100081, China. jswkysgc@126.com.
Shanshan HuHongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China. hushanshan19830219@126.com.
Qianqiu WeiHongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, 157011, China. 15945490006@163.com.

Funding

the Heilongjiang Provincial Undergraduate Colleges and Universities Central to Support the Reform and Development of Local Colleges and Universities No.2020YQ08the National Natural Science Foundation of China No.82271070the Nonprofit Central Research Institute Fund of National Research Institute for Family Planning No.2022GJZ02
6 · The paper itself

Abstract

Age-related cataract (ARC) is a degenerative change following the aging of the lens, with its specific pathogenesis still unclear. This study investigates the expression of GSK-3β, DNMT3B, and GJA3 in ARC through in vivo and in vitro studies, elucidating the regulatory mechanisms among them. Additionally, it preliminarily explores the role of DNMT3B in the epigallocatechin gallate (EGCG)-mediated delay of apoptosis in lens epithelial cells (LECs). Immunohistochemistry and Western blot results showed that the protein expression level of DNMT3B was elevated, while the protein expression levels of GJA3 and p-GSK-3β (Ser9) were decreased in the ARC group and the aged mouse group (P < 0.05). CCK-8 and Hoechst 333,42 apoptosis assays indicated that DNMT3B, GJA3, and p-GSK-3β (Ser9) were involved in H

Indexed as

ApoptosisCataractDNA (Cytosine-5-)-MethyltransferasesEpithelial CellsGlycogen Synthase Kinase 3 betaLens, CrystallineAgingAnimalsBlotting, WesternCatechinCells, CulturedDisease Models, AnimalDNA Methyltransferase 3BHumansImmunohistochemistryMaleCatechinDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3Bepigallocatechin gallateGlycogen Synthase Kinase 3 betaAge-related cataractApoptosisDNMT3BEGCGLens epithelial cells

Identifiers

PMID42316121
PMCPMC13543546

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.