Evidence map›Paper›PMID 42316094›Full record

ArticleBMC infectious diseases2026

Modeling antiretroviral therapy adherence among people living with HIV: a cross-sectional study at Pantang Hospital, Ghana.

Eric Nyarko, Irene A Kretchy, Grace Lovia Allotey-Babington, Adwoa Oforiwaa Kwakye, Benjamin Tagoe, Nathaniel Opoku Atuahene, Xoese Kalenu, Augustina Koduah, Sheila Gyasi Nimako, Kwabena Fm Opuni and 1 more

Abstract read
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Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Eric NyarkoDepartment of Statistics and Actuarial Science, School of Physical and Mathematical Sciences, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Irene A KretchyDepartment of Pharmacy Practice and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, University of Ghana, P. O. Box LG 43, Legon, Accra, Ghana. ikretchy@ug.edu.gh.
Grace Lovia Allotey-BabingtonDepartment of Pharmaceutics and Microbiology, School of Pharmacy, University of Ghana, P.O. Box LG 43, Legon, Accra, Ghana.
Adwoa Oforiwaa KwakyeDepartment of Pharmacy Practice and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, University of Ghana, P. O. Box LG 43, Legon, Accra, Ghana.
Benjamin TagoeDepartment of Pharmaceutical Science, North Dakota State University, Grand Forks, USA.
Nathaniel Opoku AtuaheneDepartment of Pharmacy Practice and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, University of Ghana, P. O. Box LG 43, Legon, Accra, Ghana.
Xoese KalenuDepartment of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
Augustina KoduahDepartment of Pharmacy Practice and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, University of Ghana, P. O. Box LG 43, Legon, Accra, Ghana.
Sheila Gyasi NimakoDepartment of Pharmacy, Pantang Hospital, Accra, Ghana.
Kwabena Fm OpuniDepartment of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
Seth Kwabena AmponsahSchool of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor adherence to antiretroviral therapy (ART) continues to undermine HIV treatment outcomes in sub-Saharan Africa, including Ghana.

objectiveThis study aimed to quantify ART treatment adherence among people living with HIV (PLHIV) at Pantang Hospital in Ghana.

methodsThis study took place from July to October 2025 among people living with HIV who receive care at Pantang Hospital in Accra, Ghana. Using random sampling, data were collected from 151 participants through interviewer-administered questionnaires assessing sociodemographic characteristics and ART adherence behaviors. A hold-back validation method was used to split the final dataset, allocating 80% to training and 20% to validation. Six machine learning models were applied to identify and rank key adherence predictors, and model performance was compared.

resultsIn all, 151 participants were recruited. Participants had a median age of 42 years; 75.5% were female, and 39.7% were older than 45 years. Most participants were Christian (88.7%), lived in peri-urban areas (70.9%), and were self-employed (72.2%). Non-adherence behaviors were common: 66.9% reported forgetting to take medication, 64.2% reported carelessness, and 85.4% reported stopping medication when feeling worse. Among the six models, Elastic Net regression demonstrated the best overall performance. The strongest predictors of non-adherence were not taking medication over the past weekend (utility estimate 0.3471, 95% confidence interval 0.2292-0.4650) and missing medication 6-10 times in the past week (utility estimate 0.2693, 95% confidence interval 0.1538-0.3848).

conclusionsThe study showed poor adherence to ART among this cohort of PLHIV which increases the risk of community-level transmission. This study provides quantitative data to help develop effective interventions to address poor adherence to improve health outcomes of PLHIV.

Indexed as

Anti-HIV AgentsDrug MonitoringHIV InfectionsMedication AdherenceAdultCross-Sectional StudiesFemaleGhanaHumansMaleMiddle AgedSurveys and QuestionnairesYoung AdultAnti-HIV AgentsART adherenceGhanaHIV/AIDSMachine learning model

Identifiers

PMID42316094
PMCPMC13602475

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.