Evidence map›Paper›PMID 42316063›Full record

SynthesisBMC cancer2026

Effect of immunonutrition on surgery outcomes in cancer patients: evidence from an umbrella review on interventional and observational meta-analyses.

Helia Mardani, Ulduz Riazi Khameneh, Ali Jafari, Sepideh Dolati, Nima Baziar, Maede Amirpour, Ghazal Zamanian, Omid Zamani, Mohammad Amin Tofighi Zavareh, Mohammad Esmail Akbari and 6 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Helia Mardani *Student Research Committee, Department of Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Ulduz Riazi Khameneh *Student´ Research Committe,Mara.C.,Islamic Azad University, Marand, Iran.
Ali JafariStudent Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sepideh DolatiDepartment of Nutrition, Ministry of Health, Tehran, Iran.
Nima BaziarClinical Research Development Center, Shahid Modarres Educational hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maede AmirpourStudent Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ghazal ZamanianSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Omid ZamaniSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Amin Tofighi ZavarehStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Esmail AkbariCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Atieh AkbariCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nasser Malekpour AlamdariCritical Care Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zeinab JavidDepatment of Nutrition, TeMS.C, Islamic Azad University, Tehran, Iran.
Jamal RahmaniCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Hossein ArdehaliDepartment of Anesthesiology and Critical Care, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. h-ardehali@sbmu.ac.ir.
Mahdi ShadnoushCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. shadnoush@sbmu.ac.ir.

Funding

Cancer Research Center, Shahid Beheshti University of Medical Sciences 43012858
6 · The paper itself

Abstract

backgroundMalnutrition is highly prevalent in cancer patients, leading to increased post-surgical complications. This umbrella review of meta-analyses aims to investigate the effect of immunonutrition on surgery outcomes in Cancer patients.

methodsMEDLINE/PubMed, SCOPUS, and WOS databases were investigated from their inception until Sep 2025. Meta-analysis investigating the impact of immunonutrition (or its components) on overall complications, infectious complications, non-infectious complications, mortality, surgical-site infections, anastomotic leak, and length of hospital stay in patients with cancer. Pooled effect sizes and CIs were calculated using a random-effects model.

resultsFifty-four studies were included in the umbrella review. The pooled results showed RR = 0.79; 95%CI: 0.70-0.88; I2 = 39.5% for postoperative overall complications, RR = 0.61; 95%CI: 0.58-0.65; I2 = 47.3% for infectious complications, RR = 0.88; 95%CI: 0.82-0.94; I2 = 0% for non-infectious complications, HR = 0.86; 95%CI: 0.74-0.99; I2 = 0% for mortality, RR = 0.66; 95%CI: 0.59-0.74; I2 = 6.5% for surgical-site infection, RR = 0.69; 95%CI: 0.62-0.77; I2 = 0% for anastomotic leak, and WMD=-1.75 days; 95%CI: -2.09,-1.41; I2 = 90.3% for length of hospital stay in immunonutrition intervention compared to control groups. Subgroup analysis by time of intervention showed that postoperative intervention is more effective in reducing overall complications (RR = 0.69; 95%CI:0.54-0.89) and the length of hospital stay (2.26 days, P = 0.001) compared to preoperative or perioperative intervention.

conclusionCancer patients undergoing surgery may benefit from immunonutrition. Postoperative intervention is more effective than pre-or perioperative intervention.

Indexed as

MalnutritionNeoplasmsPostoperative ComplicationsHumansImmunonutrition DietLength of StayObservational Studies as TopicTreatment OutcomeCancerGlutamineImmunonutritionOmega-3Surgery

Identifiers

PMID42316063
PMCPMC13543360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.