Prognostic value of controlling nutritional status score (CONUT) and prognostic nutritional index (PNI) in patients with peripheral artery disease: an evidence-based analysis.

Ying He, Xiaoci He, Meng Liu, Wei Gao, Yang Liu, Shuyun Guo

Abstract readMeta-AnalysisSystematic Review

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Synthesis in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Ying HeDepartment of Vascular Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.

Xiaoci HeThe department of health management, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.

Meng LiuDepartment of Vascular Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.

Wei GaoDepartment of Vascular Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.

Yang LiuDepartment of Vascular Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China.

Shuyun GuoDepartment of Vascular Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. guoshuyun990911@126.com.

Funding

Medical Science Research Project of Hebei 20200967

6 · The paper itself

Abstract

objectivesTo evaluate the controlling nutritional status score (CONUT) and the prognostic nutritional index (PNI) prognostic value in peripheral artery disease (PAD) patients through a meta-analysis.

methodsWe searched PubMed, Embase, Web of Science, and Cochrane databases up to November 2024. Mortality, major adverse cardiovascular events (MACE), amputation, and poor ulcer healing were extracted. Data were synthesized using odds ratios (OR) with 95% confidence intervals (CI). Sensitivity analysis assessed result stability and heterogeneity sources. All analyses were performed using Review Manager 5.4 and STATA 15.1.

resultsFifteen cohort studies with 6,830 PAD patients were included. Higher CONUT scores were linked to increased mortality (12 studies, HR: 1.34; 95% CI: 1.21-1.49) and amputation risk (6 studies, OR: 1.20; 95% CI: 1.10-1.32), while higher PNI was associated with reduced mortality (3 studies, HR: 0.95; 95% CI: 0.92-0.97) and amputation risk (2 studies, OR: 0.91; 95% CI: 0.87-0.95). No significant link was found between CONUT and MACE or poor ulcer healing. Sensitivity analysis revealed instability in the association between CONUT and poor ulcer healing.

conclusionsCONUT and PNI could predict mortality and amputation risk in PAD patients, aiding early identification of high-risk individuals. Due to the study's retrospective design and potential instability, further large-scale, multicenter prospective studies are needed to confirm these findings.

Indexed as

Decision Support TechniquesMalnutritionNutritional StatusNutrition AssessmentPeripheral Arterial DiseaseAgedAged, 80 and overAmputation, SurgicalEvidence-Based MedicineFemaleHumansLimb SalvageMaleMiddle AgedPredictive Value of TestsPrognosisControlling nutritional status scoreMeta-analysisPeripheral artery diseasePrognostic nutritional index

Identifiers

PMID42316030

DOI10.1186/s12872-026-06139-3

PMCPMC13531996

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