ReviewOncogene2026
The glycobiology of prostate cancer: an update.
Review in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Targeting Siglec-engaging immunosuppressive sialoglycans to suppress prostate cancer bone metastasis.British journal of cancer · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer is a common cancer in males and there is an urgent unmet clinical need to improve early diagnosis and identify new treatments for advanced disease. Despite huge progress in understanding changes to the genome and proteome in prostate cancer, there is a relative delay in revealing the full aspects of the prostate cancer glycome and glycoproteome. Glycobiology has been fundamental in recent discoveries in the medical field, including translational cancer research. Glycans functionally contribute to the cancer hallmarks and serve as important diagnostic biomarkers and targets for therapeutic intervention. Changes to glycans are common in prostate cancer and include increased branching of complex N-glycans, changes in sialylation, increased fucosylation, altered PSA glycosylation and the expression of truncated O-glycans. This review discusses the role of glycans in fundamental mechanisms controlling prostate cancer growth, metastasis and immune evasion. Emphasis is placed on discoveries made during the last decade, including new insights provided by N-glycan imaging mass spectrometry (IMS) profiling of prostate cancer tissues, new discoveries into the role of aberrant glycosylation in prostate tumour biology, as well as recent studies investigating glycans, glycosyltransferase enzymes and glycan binding proteins as therapeutic targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.