ArticleNature communications2026
Inducible T-bet deletion reveals tissue-specific requirements in NKp46+ ILC immunobiology and response to murine cytomegalovirus.
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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
25 authors.
Pamela Wong *Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6856-2603
Yeeun Paik *Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0004-9369-2890
Lily ChangDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Allison BurdiDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0008-1863-3961
Carly NealDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Celia C CubittDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jennifer TranDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Bishan BhattaraiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0003-1263-8554
Lyra MorinaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7361-5407
Nancy D MarinDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Kimberly HwangDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Hyogon SohnDivision of Rheumatology and Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Julia A WagnerDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2438-3873
Jennifer A FoltzDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9158-3464
Wilbur M SongDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Timothy SchappeDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Lynne MarsalaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Mark FosterDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Julia FosterDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Melissa M Berrien-ElliottDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Sytse J PiersmaDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5379-3556
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5222-4987
Wayne M YokoyamaDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0566-7264
Megan A CooperDivision of Rheumatology and Immunology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5696-172X
Todd A FehnigerDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. tfehnige@wustl.edu.ORCID 0000-0002-8705-2887
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MTargeting the Bone Marrow Microenvironment In Acute Lymphocytic LeukemiaP50CA171963 · NCI · WASHINGTON UNIVERSITY · PI Daniel C Link · 2013 to 2026
$31.6MPRE-AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGYT32HL007088 · NHLBI · WASHINGTON UNIVERSITY · PI Grant Anthony Challen, Stephen Oh · 1985 to 2026
$14.1MWashington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7MNATURAL KILLER CELL CONTROL OF MURINE CYTOMEGALOVIRUS INFECTIONR01AI131680 · NIAID · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2017 to 2025
$6.0MTRANSLATING NK CELL BIOLOGY INTO CLINICAL CANCER IMMUNOTHERAPYR01CA205239 · NCI · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2017 to 2020
$2.4MMETABOLIC REGULATION OF NATURAL KILLER CELL ACTIVATIONR01AI127752 · NIAID · WASHINGTON UNIVERSITY · PI COOPER, MEGAN ANNE · 2017 to 2021
$1.9MMICRORNA REGULATION OF NK CELL DEVELOPMENT AND FUNCTIONR01AI102924 · NIAID · WASHINGTON UNIVERSITY · PI FEHNIGER, TODD A · 2013 to 2016
$1.5MElucidating Mechanisms of CAR ML NK cell biology to treat cancer and infectionK22CA279495 · NCI · SAINT LOUIS UNIVERSITY · PI Melissa Berrien Elliott · 2024 to 2026
$558kMechanism of CD8 regulation of natural killer cell biologyF30AI161318 · NIAID · WASHINGTON UNIVERSITY · PI CUBITT, CELIA CLAIRE · 2021 to 2024
$152kElucidating the role of EOMES in Memory-Like NK cell DifferentiationF31GM146361 · NIGMS · WASHINGTON UNIVERSITY · PI TRAN, JENNIFER · 2022 to 2024
$90kNCI NIH HHS K12 CA167540NCI NIH HHS K22 CA279495NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA171963NCI NIH HHS R01 CA205239NHLBI NIH HHS T32 HL007088NIAID NIH HHS F30 AI161318NIAID NIH HHS R01 AI102924NIAID NIH HHS R01 AI127752NIAID NIH HHS R01 AI131680NIGMS NIH HHS F31 GM146361U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) K12CA167540U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) K22CA279495U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA091842U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P50CA171963U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA205239U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI102924U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI127752U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI131680
Abstract
The requirement for the T-box transcription factors (TF) T-bet and Eomes in innate lymphoid cells (ILCs) beyond their development is not well understood. Here, we generate an inducible, NKp46-specific T-bet knock-out (KO) model and compare it to corresponding Eomes KO and combined T-bet Eomes double KO mice to define T-box TFs requirement in the homeostasis and function of mature NK cell and other NKp46
Indexed as
Antigens, LyHerpesviridae InfectionsLymphocytesMuromegalovirusNatural Cytotoxicity Triggering Receptor 1T-Box Domain ProteinsAnimalsFemaleImmunity, InnateIntestine, SmallKiller Cells, NaturalLiverMiceMice, Inbred C57BLMice, KnockoutOrgan SpecificityAntigens, LyEomes protein, mouseNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouseT-bet Transcription FactorT-Box Domain Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.