Evidence map›Paper›PMID 42315719›Full record

ArticleJournal of fluorescence2026

Nitrogen-Doped Carbon Quantum Dots for FRET-Assisted and Smartphone-Enabled Fluorescent Detection of Melatonin in Biological Samples.

Priyanka K M, Himanshu Kumar, Hsin-Chieh Kung, Ya-Ping Chung, Anshu Kumar, Vishal Kumar, Bo-Wun Huang, Balasubramanian Sriram, Sea-Fue Wang, Chih-Lung Wang and 3 more

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Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Priyanka K M *Department of Chemistry, School of Science, IFTM University, Moradabad, U.P., 244102, India.
Himanshu Kumar *Department of Chemistry, School of Science, IFTM University, Moradabad, U.P., 244102, India.
Hsin-Chieh KungCenter for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, 833301, Taiwan.
Ya-Ping ChungDepartment of Leisure and Sports Management, Cheng Shiu University, Kaohsiung, 833301, Taiwan.
Anshu KumarInstitute of Analytical and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013, Taiwan.
Vishal KumarQuantum Materials and Devices Unit, Institute of Nano Science and Technology, Sector 81, Knowledge City, Sahibzada Ajit Singh Nagar, Punjab, 140306, India.
Bo-Wun HuangDepartment of Mechanical Engineering, Institute of Mechatronic Engineering, Cheng Shiu University, Kaohsiung, 833301, Taiwan.
Balasubramanian SriramDepartment of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, 106, Taiwan.
Sea-Fue WangDepartment of Materials and Mineral Resources Engineering, National Taipei University of Technology, Taipei, 106, Taiwan.
Chih-Lung WangCenter for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, 833301, Taiwan.
Yung-Lung ChenDivision of Cardiology, Department of Internal Medicine, College of Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, Kaohsiung, 833, Taiwan. feymanchen@gmail.com.
Amanpreet KaurDepartment of Chemistry, School of Science, IFTM University, Moradabad, U.P., 244102, India. amanpreet2225@gmail.com.
Sakthivel KogularasuCenter for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung, 833301, Taiwan. kogularasu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melatonin (N-acetyl-5-methoxytryptamine, MLT) is an endogenous neurohormone that regulates circadian rhythms, exhibits potent antioxidant activity, and has been implicated in cancer suppression and neuroprotection. In this study, we report the design and development of a highly sensitive optical nanosensor based on nitrogen-doped carbon quantum dots (N-CQDs) for the quantitative detection of MLT in human blood. The N-CQDs were synthesized via a facile pyrolysis route, yielding uniform nanodots that exhibit strong blue photoluminescence. Comprehensive structural, morphological, and optical characterizations were conducted using X-Ray Diffraction (XRD), transmission electron microscopy (TEM), and fluorescence spectroscopy, confirming the successful incorporation of nitrogen functionalities with a photoluminescence quantum yield of 36.6%. The synthesized N-CQDs exhibit a highly selective and sensitive detection towards MLT, and the sensing mechanism is plausibly governed by Förster resonance energy transfer (FRET)-mediated quenching of N-CQD emission upon interaction with MLT. This developed probe of N-CQDs achieved an impressive detection limit of 4.68 nM, demonstrating its potential for biomedical diagnostic applications. Furthermore, the system was successfully integrated into a smartphone-assisted sensing platform for portable and real-time MLT monitoring. Quantitative analysis of spiked human blood samples exhibited excellent recovery values ranging from 96.1% to 104.2%, validating the reliability and applicability of the proposed N-CQD-based sensor for clinical and point-of-care analysis.

Indexed as

Carbon Quantum DotsFluorescence Resonance Energy TransferFluorescent DyesMelatoninNitrogenQuantum DotsSmartphoneCarbonFluorescenceHumansCarbonFluorescent DyesMelatoninNitrogenCarbon quantum dotsFluorescent detectionFörster resonance energy transferMelatonin biosensorReal-time monitoring

Identifiers

PMID42315719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.