ArticleNature communications2026
Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic pain.
Haiting Fan, Yingying Su, Jie Deng, Zhengkai Liang, Meiying Chen, Kaibin Wu, Peiwen Tang, Chen Wang, Deyi Kong, Ting Xu and 4 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Haiting Fan *Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID 0009-0004-8481-2221 Yingying Su *Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology and Pain Research Center, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou, China.
Jie Deng *Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhengkai Liang *Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Meiying ChenGuangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology and Pain Research Center, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou, China.
Kaibin WuGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, School of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0003-3386-3630 Peiwen TangGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
Chen WangDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Deyi KongGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, School of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0009-0003-6940-6164 Ting XuGuangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology and Pain Research Center, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou, China.ORCID 0000-0001-6123-9814 Feixue LiangGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, School of Biomedical Engineering, Southern Medical University, Guangzhou, China. liangfx@smu.edu.cn.ORCID 0009-0007-8513-9683 Wenjun XinGuangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology and Pain Research Center, Zhongshan Medical School, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou, China. xinwj@mail.sysu.edu.cn.ORCID 0000-0002-5380-8738 Yan WuDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. wuyan27@mail.sysu.edu.cn.ORCID 0000-0002-8920-2340 Xia FengDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. fengxia@mail.sysu.edu.cn.ORCID 0000-0001-8182-9803 Funding
China Postdoctoral Science Foundation 2024M763800National Natural Science Foundation of China (National Science Foundation of China) 32471062National Natural Science Foundation of China (National Science Foundation of China) 82071224National Natural Science Foundation of China (National Science Foundation of China) 82371189National Natural Science Foundation of China (National Science Foundation of China) 82401449National Natural Science Foundation of China (National Science Foundation of China) 82501483National Natural Science Foundation of China (National Science Foundation of China) 82572936
6 · The paper itselfAbstract
Chronic pain and sleep disorders frequently co-occur and exacerbate each other, yet the neural mechanisms underlying this comorbidity remain poorly understood. Here, we found that hyperactivity of GABAergic neurons in the dorsal division of the lateral septum (LS
Indexed as
DexmedetomidineGABAergic NeuronsHyperalgesiaNeuralgiaSeptal NucleiSleepAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLReceptors, Adrenergic, alpha-2Sleep Wake DisordersDexmedetomidineReceptors, Adrenergic, alpha-2
Identifiers
PMID42315515
PMCPMC13434266
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