Evidence map›Paper›PMID 42315508›Full record

ArticleNature communications2026

Conformational landscape and ligand-dependent clustering of the human type 2 IP

Caifeng Liu, Yu-Jing Lan, Max G Kushner, Qingyu Tang, Erkan Karakas

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Caifeng LiuDepartment of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN, USA.
Yu-Jing LanDepartment of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN, USA.ORCID 0000-0002-5971-5284
Max G KushnerDepartment of Cell and Developmental Biology, Vanderbilt University, School of Medicine, Nashville, TN, USA.
Qingyu TangDepartment of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN, USA.ORCID 0000-0002-5554-6540
Erkan KarakasDepartment of Molecular Physiology and Biophysics, Vanderbilt University, School of Medicine, Nashville, TN, USA. erkan.karakas@vanderbilt.edu.ORCID 0000-0001-6552-3185

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Thermo Scientific Glacios cryo-TEMS10OD030292 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2021 to 2021
$2.0M
Structure and function of inositol triphosphate receptorsR01GM141251 · NIGMS · VANDERBILT UNIVERSITY · PI KARAKAS, ERKAN · 2021 to 2024
$1.4M
TFS Talos-L120C, a 120kV transmission electron microscope for structural studiesS10OD036307 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2024 to 2024
$656k
Network-Attached Biomedical Research Data Management SystemS10RR031634 · NCRR · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2011 to 2011
$600k
Spinning Disk Super Resolution Confocal Microscope for the Vanderbilt Brain InstituteS10MH130456 · NIMH · VANDERBILT UNIVERSITY · PI SCHAFER, JENNY · 2023 to 2023
$598k
NCI NIH HHS P30 CA068485NCRR NIH HHS S10 RR031634NEI NIH HHS P30 EY008126NIDDK NIH HHS P30 DK058404NIGMS NIH HHS R01 GM141251NIH HHS S10 OD030292NIH HHS S10 OD036307NIMH NIH HHS S10 MH130456U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM141251
6 · The paper itself

Abstract

Inositol 1,4,5-trisphosphate (IP

Indexed as

Inositol 1,4,5-Trisphosphate ReceptorsAdenosine TriphosphateCalciumCalcium SignalingCryoelectron MicroscopyHEK293 CellsHumansInositol 1,4,5-TrisphosphateLigandsModels, MolecularProtein BindingProtein ConformationAdenosine TriphosphateCalciumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsLigands

Identifiers

PMID42315508
PMCPMC13433952

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.