Evidence map›Paper›PMID 42315493›Full record

SynthesisDiabetes, obesity & metabolism2026

Short-Term Versus Long-Term Efficacy of Endoscopic Sleeve Gastroplasty in 8880 Obese Patients: A Systematic Review and Meta-Analysis.

Mohammed Barghash, Matthew Riad, Yasser Khalil, Khaled Mohamed, Ahmed Elgamasy, Omar Aly, Mohanad Abdelfattah, Mohamed Ibrahim Elgohary, Zeyad M Wesh, Thilo Sprenger and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohammed BarghashNorth Bristol Foundation NHS Trust, Bristol, UK.
Matthew RiadFaculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0009-0002-5069-1658
Yasser KhalilMedical Intern at Faculty of Medicine, Helwan University, Cairo, Egypt.ORCID 0009-0005-3711-5412
Khaled MohamedGeneral Surgery Resident at Cairo University Hospitals, Cairo University, Cairo, Egypt.ORCID 0000-0002-0139-2873
Ahmed ElgamasyFaculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0009-0008-4169-5271
Omar AlyFaculty of Medicine, Port Said University, Port Said, Egypt.ORCID 0009-0008-6606-648X
Mohanad AbdelfattahCairo University Hospitals, Cairo, Egypt.ORCID 0000-0002-8598-2052
Mohamed Ibrahim ElgoharyFaculty of Medicine, Newgiza University, Cairo, Egypt.ORCID 0009-0003-0104-4443
Zeyad M WeshFaculty of Medicine, Alexandria University, Alexandria, Egypt.ORCID 0009-0008-8748-6299
Thilo SprengerHead of the Bariatric Surgery Department, Recklinghausen, Germany.
Hany TaklaOrlando Health Weight Loss and Bariatric Surgery Institute, Orlando, Florida, USA.ORCID 0009-0001-3070-1858
Amr ElserafyDepartment of Trauma and Emergency General Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.ORCID 0000-0002-5387-4604
Ahmed AbdelsamadDepartment of Surgery II, University of Witten/Herdecke, Herdecke, Germany.ORCID 0000-0002-5451-4504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic sleeve gastroplasty (ESG), a natural orifice transluminal endoscopic procedure, is increasingly integrated into multidisciplinary obesity care. We performed a systematic review and meta-analysis to quantify the durability of ESG-associated weight loss and metabolic outcomes across short- and long-term follow-up.

methodsDatabases were searched from inception to September 2, 2025 (PROSPERO: CRD420251139333). Peer-reviewed studies reporting ESG outcomes were included; primary outcomes were % total body weight loss (%TBWL), % excess body weight loss (%EBWL), and BMI reduction, stratified by follow-up (≤ 6 months vs. ≥ 1 year). Random-effects models were used; heterogeneity (I

resultsThirty-three studies (8880 patients; 31 cohorts, 2 RCTs) were included. %TBWL increased from 8.66% (1 month) to 16.13% (6 months) and was 17.88% at 1 year. Long-term pooled %TBWL declined modestly over time (17.88% at 1 year to 15.67% at 3 years). Remission rates were 62% for type 2 diabetes, 43% for hypertension, and 43% for dyslipidaemia. Weight regain occurred in 6%. Baseline BMI predicted higher %TBWL but lower %EBWL.

conclusionESG is associated with clinically meaningful weight loss maintained beyond 6 months with modest attenuation over longer follow-up, alongside favourable metabolic remission rates and low reported weight regain.

Indexed as

GastroplastyObesityObesity, MorbidBody Mass IndexHumansTime FactorsTreatment OutcomeWeight Lossbariatric endoscopycomorbidity remissionendoscopic sleeve gastroplasty (ESG)long‐term outcomesobesityshort‐term outcomessystematic review and meta‐analysisweight loss

Identifiers

PMID42315493
PMCPMC13449078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.