Evidence map›Paper›PMID 42315480›Full record

Observational studyAllergy2026

Clinical Features of Cellular Senescence Pathways in Severe Asthma.

Woo-Jung Song, Nazanin Zounemat Kermani, Ali Versi, Stephany Sánchez-Ovando, Jodie Louise Simpson, Peter A Wark, Katherine Joanne Baines, Sven-Erik Dahlén, Ratko Djukanovic, Yike Guo and 3 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01982162 (Protocol for the European Multi-Centre Study Understanding Severe Asthma Longitudinal Assessment of Children With Severe Asthma and Severe Pre-school Wheeze), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01982162 completednot on this map

Protocol for the European Multi-Centre Study Understanding Severe Asthma Longitudinal Assessment of Children With Severe Asthma and Severe Pre-school Wheeze

TypeobservationalSponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2011 to 2014Enrolled300ConditionsAsthma
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Woo-Jung SongDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4630-9922
Nazanin Zounemat KermaniDepartment of Computing, Data Science Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-2479-3861
Ali VersiNational Heart and Lung Institute, Imperial College London, London, UK.
Stephany Sánchez-OvandoPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
Jodie Louise SimpsonPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
Peter A WarkPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
Katherine Joanne BainesPriority Research Centre for Healthy Lungs, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
Sven-Erik DahlénCentre for Allergy Research, Karolinska Institute, Stockholm, Sweden.
Ratko DjukanovicFaculty of Medicine, Southampton University, Southampton, UK.
Yike GuoDepartment of Computing, Data Science Institute, Imperial College London, London, UK.
Ian M AdcockNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0003-2101-8843
Kian Fan ChungNational Heart and Lung Institute, Imperial College London, London, UK.ORCID https://orcid.org/0000-0001-7101-1426
U‐BIOPRED Study Group

Funding

European Federation of Pharmaceutical Industries and AssociationsEuropean Union's Seventh Framework Programme FP7/2007-2013Innovative Medicines Initiative Joint Undertaking 115010John Hunter Hospital Charitable TrustUK Research and Innovation
6 · The paper itself

Abstract

backgroundAsthma severity increases with age, suggesting a role for accelerated biological ageing. We hypothesised that cellular senescence pathways such as the senescence-associated secretory pathway (SASP) and the p53-cellular senescence pathway are enriched in the airways of patients with severe asthma.

methodsWe utilised transcriptomic data from the U-BIOPRED cohort to analyse enrichment scores (ES) of p53 and SASP pathways in different airway compartments using gene set variation analysis. Findings in bronchial biopsies were validated in the independent NOVA cohort. We examined associations between senescence ES, clinical parameters and other asthma-related gene signatures. Functional clusters of the SASP gene set were also explored.

resultsIn the U-BIOPRED cohort, p53 and SASP ES were significantly elevated in bronchial biopsies of severe asthmatics compared to mild-to-moderate asthmatics and healthy volunteers, with SASP enrichment validated in the NOVA cohort. In bronchial biopsies, higher senescence ES correlated with frequent exacerbations, oral corticosteroid use, comorbid nasal polyps and lower FEV1%. No significant enrichment was found in other airway samples according to asthma severity. In nasal brushings, SASP ES was significantly higher in participants with comorbid nasal polyps. A distinct SASP functional cluster related to lung injury and repair (Cluster 2) was strongly associated with clinical severity and nasal polyps. Senescence signatures correlated positively with oxidative phosphorylation and macrophage activation signatures, but not with eosinophil signatures.

conclusionsCellular senescence pathways are enriched in severe asthmatic bronchial tissues and correlate with disease severity, remodelling and nasal polyps. These findings warrant further investigation into their therapeutic implications.

trial registrationNCT01982162.

Indexed as

AsthmaCellular SenescenceAdultBiomarkersBiopsyFemaleGene Expression ProfilingHumansMaleMiddle AgedSenescence-Associated Secretory PhenotypeSeverity of Illness IndexSignal TransductionTranscriptomeTumor Suppressor Protein p53BiomarkersTumor Suppressor Protein p53cellular senescencenasal polypsp53senescence‐associated secreted phenotypesevere asthma

Identifiers

PMID42315480
PMCPMC13569611

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.