Evidence map›Paper›PMID 42315354›Full record

Trial reportThe Laryngoscope2026

Transoral Ultrasound in the Diagnostic Workup of Peritonsillar Abscess-A Randomized Clinical Trial.

Tobias Todsen, Mads G Stage, Jacob Melchiors, Mathias Mejdahl, Amalie P Posselt, Anders R Madsen, Christoffer H Hahn, Christian Godballe, Sanne H Michaelsen

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tobias TodsenDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Denmark.
Mads G StageDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Denmark.
Jacob MelchiorsDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Denmark.
Mathias MejdahlThe Department of Orthopedic Surgery, Copenhagen University Hospital-Amager and Hvidovre Hospital, Denmark.
Amalie P PosseltDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Denmark.ORCID https://orcid.org/0000-0002-4389-2040
Anders R MadsenDepartment of Otolaryngology, Head and Neck Surgery, and Audiology, Odense University Hospital, Odense, Denmark.
Christoffer H HahnDepartment of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Denmark.
Christian GodballeDepartment of Otolaryngology, Head and Neck Surgery, and Audiology, Odense University Hospital, Odense, Denmark.
Sanne H MichaelsenDepartment of Otolaryngology, Head and Neck Surgery, and Audiology, Odense University Hospital, Odense, Denmark.

Funding

OUH og Rigshospitalets fælles forskningspulje
6 · The paper itself

Abstract

backgroundPeritonsillar abscess (PTA) is a common deep head and neck infection in younger adults. Because the condition can be difficult to distinguish from peritonsillar cellulitis on clinical examination, many patients undergo unnecessary diagnostic blind needle aspiration attempts. For this reason, transoral ultrasound has been suggested as a point-of-care imaging modality that may improve the diagnostic workup of PTA. This randomized clinical trial explores whether transoral ultrasound improves the management of patients with peritonsillar infection.

methodsA multicenter randomized clinical trial was conducted at the departments of Otorhinolaryngology, Head and Neck Surgery at Copenhagen University Hospital-Rigshospitalet and Odense University Hospital in Denmark. Patients suspected of having a peritonsillar abscess were randomized to either standard clinical examination (control group) or standard clinical examination combined with transoral ultrasound (intervention group).

resultsNinety-five patients (58 at Rigshospitalet and 37 at Odense University Hospital) were included in the study by 28 different physicians. Forty-seven patients were allocated to the intervention group and 48 to the control group. The diagnostic accuracy was 80.9% in the intervention group versus 72.9% in the control group (p = 0.50). In the control group, 18 (37.5%) underwent unsuccessful needle aspirations compared to 12 (26.0%) in the intervention group. The intervention group underwent 31.9% fewer needle aspiration attempts compared with the control group (p < 0.01).

conclusionTransoral ultrasound can significantly decrease the number of needle aspiration attempts in patients with a suspected peritonsillar abscess. Still, we could not find any significant improvement in diagnostic accuracy or improved patient outcomes. LEVEL OF EVIDENCE: 2:

Indexed as

Peritonsillar AbscessAdultDenmarkDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPoint-of-Care SystemsUltrasonographyinfectionminimally invasive therapyoropharynxperitonsillar abscessultrasound/imaging

Identifiers

PMID42315354
PMCPMC13669993

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.