ArticleThe Journal of international medical research2026
Dietary fiber intake and gallstones: The mediating role of serum lipids.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
ObjectiveTo investigate the mediating role of serum lipids in the association between dietary fiber intake and gallstones prevalence.MethodsThis study analyzed the data from 4896 adults participating in the National Health and Nutrition Examination Survey conducted between 2017-March 2020 and August 2021-August 2023. Logistic regression models and subgroup analyses were conducted to assess the correlation between dietary fiber intake and gallstone prevalence. Additionally, smooth curve fitting based on the generalized additive model was applied to elucidate nonlinear relationships. The mediating effects of lipid-related indicators, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, total cholesterol, non-high-density lipoprotein cholesterol, residual cholesterol, and atherogenic index of plasma were also evaluated.ResultsHigh-density lipoprotein cholesterol and atherogenic index of plasma significantly mediated the association between dietary fiber intake and gallstone prevalence, with mediation proportions of 5.06% and 4.26%, respectively (all
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