ArticleInternational journal of radiation oncology, biology, physics2026
No Evidence for Depletion of Circulating Lymphocyte Populations in Primary Brain Tumor Patients Receiving Radiation Therapy Alone.
Article in International journal of radiation oncology, biology, physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the impact of radiation therapy (RT) for brain tumors on circulating lymphocyte populations and understand this from a dosimetric perspective. METHODS AND MATERIALS: This prospective study enrolled patients with primary brain tumors treated with either photon or proton RT. To specifically study the effect of RT, only patients without concurrent chemotherapy were eligible. For each patient, blood samples were collected before, during, and after RT, as well as at the first follow-up, for flow cytometry analysis of blood cells. We used a stochastic model to compute blood dose distributions from treatment plans and patient-specific blood flow simulations. Dose to the lymph nodes (LNs) in the head and neck region was also assessed. Dose distributions and lymphocyte trends from patients treated with photon versus proton therapy were compared.
resultsThirty-five patients with a median age of 50 were included: 27 patients with benign tumors (mostly meningiomas) and 8 with malignant tumors (mostly gliomas). There were no significant RT-induced changes in either the total lymphocyte count or its subpopulations in this patient cohort. In line with this finding, dosimetric analyses showed that total blood doses were ∼0.1 to 0.2 Gy and that most LNs in the head and neck area are spared. Proton RT was associated with a greater dosimetric sparing of both blood and LNs.
conclusionsIn this exploratory analysis, we found no evidence that RT alone results in significant changes in peripheral lymphocyte counts in patients with primary brain tumors treated to limited intracranial volumes. The lack of apparent RT-induced cytotoxicity is consistent with the limited dose received by either the blood or the regional LNs.
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