ArticleNeurotoxicology2026
Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer's disease.
Erratum issuedAbstract readTwin Study
In one paragraph
Article in Neurotoxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Authors and funding
23 authors.
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way, Floor 2, Suite 246, Marina Del Rey, CA 90292, USA; Department of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA. Electronic address: salminen@usc.edu.
Xinhui WangDepartment of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA. Electronic address: xinhuiwa@usc.edu.
Andrew J PetkusDepartment of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Radiology, University of California San Diego, La Jolla, 8929 University Center Ln, Ste 101, San Diego, CA 92122, USA; Center for Behavior Genetics of Aging, University of California San Diego, 9500 Gilman Drive, Mail Code 0664, La Jolla, CA 92093, USA.
Jeremy A ElmanDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Center for Behavior Genetics of Aging, University of California San Diego, 9500 Gilman Drive, Mail Code 0664, La Jolla, CA 92093, USA.
Donald J HaglerDepartment of Radiology, University of California San Diego, La Jolla, 8929 University Center Ln, Ste 101, San Diego, CA 92122, USA; Center for Multimodal Imaging and Genetics, University of California San Diego, 9500 Gilman Drive, Mail Code 0841, La Jolla, CA 92093, USA.
Joel D KaufmanDepartments of Environmental & Occupational Health Sciences, Medicine, and Epidemiology, University of Washington, 3980 15th Ave NE. Second floor, Seattle, WA 98195, USA.
Joshua MillsteinDepartment of Population and Public Health Sciences, University of Southern California, 1845 N Soto St, Los Angeles, CA 90032, USA.
Meredith N BraskieImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way, Floor 2, Suite 246, Marina Del Rey, CA 90292, USA; Department of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA.
Joshua LiuImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way, Floor 2, Suite 246, Marina Del Rey, CA 90292, USA; Department of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA.
Hyung Jin ChoImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way, Floor 2, Suite 246, Marina Del Rey, CA 90292, USA; Department of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA.
Deydeep KothapalliImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way, Floor 2, Suite 246, Marina Del Rey, CA 90292, USA; Department of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, 4676 Admiralty Way, Floor 2, Suite 246, Marina Del Rey, CA 90292, USA; Department of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA.
Daniel P BeaversDepartments of Statistical Sciences, Wake Forest University, Winston-Salem, NC 27101, USA.
Mark A EspelandDepartment of Biostatistics and Data Sciences, Wake Forest School of Medicine, 475 Vine Street, Winston-Salem, NC 27101, USA; Department of Internal Medicine, Wake Forest School of Medicine, 475 Vine Street, Winston-Salem, NC 27101, USA.
Margaret GatzCenter for Economic and Social Research, University of Southern California, 635 Downey Way, VPD, Los Angeles, CA 90089, USA.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA.
Ira FrahmandDepartment of Medicine, University of Wisconsin - Madison, 1685 Highland Ave, Madison, WI 53705, USA.
Stephen R RappDepartments of Psychiatry & Behavioral Medicine, Social Sciences & Health Policy, Wake Forest School of Medicine, 791 Jonestown Road, Winston-Salem, NC 27103, USA.
Caleb E FinchAndrus Gerontology Center, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089, USA.
Jiu-Chiuan ChenDepartment of Neurology, University of Southern California, 1540 Alcazar Street, Suite 215, Los Angeles, CA 90033, USA; Department of Population and Public Health Sciences, University of Southern California, 1845 N Soto St, Los Angeles, CA 90032, USA.
William S KremenDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Center for Behavior Genetics of Aging, University of California San Diego, 9500 Gilman Drive, Mail Code 0664, La Jolla, CA 92093, USA.
Carol E FranzDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Center for Behavior Genetics of Aging, University of California San Diego, 9500 Gilman Drive, Mail Code 0664, La Jolla, CA 92093, USA.
Funding
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG · 1985 to 2019
$41.0MThe VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0MUSCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8MWake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3MWake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WILLIAMSON, JEFF DOUGLAS · 2016 to 2020
$12.2MUrban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5MThe VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7MAlzheimer's Disease & Related Dementias: Geography, Environments, and MechanismsRF1AG054068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2016 to 2016
$4.1MEnvironmental Determinants of Pathological Brain Aging in WHI Memory StudiesR01ES025888 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, KAUFMAN, JOEL DANIEL · 2016 to 2020
$3.2MWorldwide Mapping of Air Pollution Exposure Patterns on Aging Brain HealthR01ES033961 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Lauren E. Salminen · 2022 to 2026
$2.7MEnvironmental Determinants of Cognitive Aging in the WHI Memory StudyR01AG033078 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2011 to 2014
$2.6MNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIA NIH HHS P01 AG055367NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072947NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG033078NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG076838NIA NIH HHS RF1 AG054068NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES025888NIEHS NIH HHS R01 ES033961
Abstract
introductionAmbient air pollution increases Alzheimer's disease (AD) risk, yet exposure associations with cortical thickness (CTh) in AD-vulnerable brain regions is unclear. Here we examined the associations between PM
methodsWe conducted a cross-sectional study using data from 387 VETSA men (M
resultsIn WHIMS, exposures were negatively associated with CTh in the AD meta-ROI (p DISCUSSION: Positive associations in younger VETSA men, coupled with negative associations in older WHIMS women, may suggest nonmonotonic AD-related neurodegeneration.
Indexed as
Air PollutionAlzheimer DiseaseBrain Cortical ThicknessCerebral CortexAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParticulate MatterParticulate MatterAir pollutionAlzheimer’s diseaseBrain agingCortical thicknessStructural MRI
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.