Observational studyInternational journal of cardiology2026
Effect of glycemic status on the natural history of left atrial structure and function in adults with metabolic syndrome and obesity.
Observational study in International journal of cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInformation on the natural history of left atrial (LA) echocardiographic parameters in patients with metabolic syndrome (MS) and obesity is limited. We investigated the association between glycemic status and markers of LA structure and function.
methodsLongitudinal, prospective, multicenter study in patients with MS and a body mass index ≥27 and < 40 kg/m
resultsWe analyzed 553 participants (mean age 65 ± 5 years; 40% women) with normoglycemia (n = 68), prediabetes (n = 287), or diabetes (n = 198). Compared with baseline, at 5 years the LA volume index increased (22.9 ± 7 to 27.1 ± 8.9, p < 0.0001), LA reservoir strain decreased (27.8 ± 6.5 to 23.3 ± 6.6, p < 0.0001), LA stiffness index increased (0.35 ± 0.17 to 0.41 ± 0.26, p < 0.0001), LA function index decreased (67.3 ± 29.2 to 55.8 ± 24.3, p < 0.0001), and the left atrioventricular coupling index increased (21.7 ± 10.5 to 32.2 ± 20.3, p < 0.0001). No association was found between glycemic status and LA echocardiographic parameters of atrial function.
conclusionsIn a population with MS and obesity but free of cardiovascular disease, glycemic status was not strongly associated with longitudinal changes in echocardiographic markers of LA structure or function. In all three groups, echocardiographic parameters worsened significantly during follow-up.
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