Evidence map›Paper›PMID 42314784›Full record

ArticleJournal of affective disorders2026

Sterol carrier protein 2 loss reduces anxiety and enhances fear extinction.

Elizabeth Sabens Liedhegner, Kara L Stuhr, Elizabeth M Doncheck, Jennifer Tinklenberg, Samantha Pollock, Jennifer Sterrett, Ozge Gunduz-Cinar, Cecilia J Hillard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizabeth Sabens LiedhegnerDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America. Electronic address: liedhegn@uwm.edu.
Kara L StuhrDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America.
Elizabeth M DoncheckDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America.
Jennifer TinklenbergDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America.
Samantha PollockDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America.
Jennifer SterrettDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America.
Ozge Gunduz-CinarLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20852, United States of America.
Cecilia J HillardDepartment of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America.

Funding

BIOCHEMISTRY OF ANANDAMIDE, AN ENDOGENOUS CANNABINOIDR01DA009155 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI HILLARD, CECILIA J · 1996 to 2011
$3.4M
Development of sterol carrier protein 2 inhibitors as anxiolyticsR01MH133315 · NIMH · MEDICAL COLLEGE OF WISCONSIN · PI CHRISTOPHER W CUNNINGHAM, Cecilia J Hillard · 2024 to 2026
$2.0M
NIDA NIH HHS R01 DA009155NIMH NIH HHS R01 MH133315
6 · The paper itself

Abstract

Brain endocannabinoid (eCB) signaling, which includes CB1 cannabinoid receptors (CB1R) and the eCBs N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), modulates behavioral responses to stress and fear extinction. Sterol carrier protein 2 (SCP-2) is an intracellular lipid binding protein expressed in brain that binds AEA and 2-AG at nanomolar concentrations and facilitates their cellular accumulation. SCP-2 mRNA is present in mouse limbic brain regions and is increased in the prefrontal cortex (PFC) and amygdalar complex in mice with impaired (129S1/Sv1mJ) fear extinction compared to mice with normal (C57BL/6J) fear extinction. In this study, we utilized mice with deletion of the gene for SCP-2 and an overlapping gene, SCP-X (SCP-2/X

Indexed as

AnxietyCarrier ProteinsExtinction, PsychologicalFearAmygdalaAnimalsArachidonic AcidsEndocannabinoidsGlyceridesMaleMiceMice, Inbred C57BLMice, KnockoutPiperidinesPolyunsaturated AlkamidesPyrazolesArachidonic AcidsCarrier ProteinsEndocannabinoidsGlyceridesPiperidinesPolyunsaturated AlkamidesPyrazolesReceptor, Cannabinoid, CB1sterol carrier proteins2-ArachidonoylglycerolCannabinoid tetradEndocannabinoidN-arachidonoylethanolamineSterol carrier protein 2Sterol carrier protein-X

Identifiers

PMID42314784
PMCPMC13361652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.