Evidence map›Paper›PMID 42314770›Full record

ArticleAmerican journal of physiology. Cell physiology2026

Redox-sensitive GPCR signaling drives Gq-dependent Ca

Jessica Lapiro, Yotesawee Srisomboon, Kayla Law, Scott M O'Grady

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica LapiroDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.ORCID 0000-0003-3236-299X
Yotesawee SrisomboonDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.
Kayla LawDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.ORCID 0000-0003-3560-8465
Scott M O'GradyDepartment of Animal Science, University of Minnesota, St. Paul, Minnesota, United States.ORCID 0000-0002-0474-5451

Funding

Mechanisms of IL-33 secretion in allergic diseasesR01AI128729 · NIAID · MAYO CLINIC ROCHESTER · PI Hirohito Kita, SCOTT M. O'GRADY · 2017 to 2026
$5.6M
Allergen-induced extracellular DNA in type 2 immunityR01AI169530 · NIAID · MAYO CLINIC ARIZONA · PI KITA, HIROHITO, O'GRADY, SCOTT M. · 2022 to 2025
$3.2M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI128729HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI169530NIAID NIH HHS R01 AI128729NIAID NIH HHS R01 AI169530UMN | Minnesota Agricultural Experiment Station (MAES) AES0016134
6 · The paper itself

Abstract

Organic dust (OD) from animal production facilities contains a complex mixture of microbial products, metabolites, and particulates that engage airway epithelial signaling pathways. Here we investigated the mechanisms by which OD extract (ODE) activates immune signaling pathways in human bronchial epithelial cells. ODE rapidly stimulate reactive oxygen species (ROS) generation and a biphasic increase in intracellular Ca

Indexed as

BronchiCalciumCalcium SignalingCytokinesEpithelial CellsGTP-Binding Protein alpha Subunits, Gq-G11Receptors, G-Protein-CoupledHumansOxidation-ReductionPeptides, CyclicReactive Oxygen SpeciesReceptors, LeukotrieneSignal TransductionCalciumCytokinesGTP-Binding Protein alpha Subunits, Gq-G11Peptides, CyclicReactive Oxygen SpeciesReceptors, G-Protein-CoupledReceptors, LeukotrieneYM-254890airway epitheliumairway inflammationautocrine signalingorganic dust

Identifiers

PMID42314770
PMCPMC13359508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.