Evidence map›Paper›PMID 42314769›Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2026

Gut microbiota-generated trimethylamine

Eleni Laskaridou, Cortney N Steele, Glen R Reid, Janet T Rinehart, Elaina L Marinik, Kristen R Howard, Brenda M Davy, Michael G Sweet, Andrew P Neilson, Kevin P Davy

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Gut microbiota-generated trimethylamineAmerican journal of physiology. Endocrinology and metabolism · 2026
    Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eleni LaskaridouDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.ORCID 0000-0003-2862-6673
Cortney N SteeleDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.ORCID 0000-0002-5701-1240
Glen R ReidDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.
Janet T RinehartDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.
Elaina L MarinikDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.ORCID 0009-0004-6281-1789
Kristen R HowardDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.ORCID 0000-0003-1241-9565
Brenda M DavyDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.
Michael G SweetPlants for Human Health Institute, North Carolina State University, Kannapolis, North Carolina, United States.
Andrew P NeilsonPlants for Human Health Institute, North Carolina State University, Kannapolis, North Carolina, United States.
Kevin P DavyDepartment of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, Virginia, United States.ORCID 0000-0001-9115-5013

Funding

Gut Microbiota-Generated TMAO & Glucose Homeostasis in Older AdultsR21AG067380 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DAVY, KEVIN P · 2020 to 2021
$444k
Gut Microbiota, Trimethylamine N-Oxide, and Endothelial Dysfunction in Middle-Aged AdultsR21AG058931 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DAVY, KEVIN P · 2018 to 2019
$434k
HHS | National Institutes of Health (NIH) NCT03327805NIA NIH HHS R21 AG058931NIA NIH HHS R21 AG067380
6 · The paper itself

Abstract

The causal relationship between gut microbiota-generated trimethylamine

Indexed as

Blood GlucoseCholineGastrointestinal MicrobiomeGlucoseMethylaminesAdultCross-Over StudiesDouble-Blind MethodFemaleGlucose Tolerance TestHomeostasisHumansInsulin ResistanceMaleMiddle AgedYoung AdultBlood GlucoseCholineGlucoseMethylaminestrimethyloxaminecardiometabolic riskglucose tolerancehost-microbe interactionsinsulin sensitivity

Identifiers

PMID42314769
PMCPMC13398441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.