ReviewCurrent opinion in genetics & development2026
Active processes shape and move the genome and nucleoplasm.
Review in Current opinion in genetics & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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1 author.
Funding
Abstract
Active processes are omnipresent in the cell nucleus. From genome-based activities such as transcription and replication, to metabolic activity in the nucleoplasm and its liquid condensates, the nucleus is far from thermodynamic equilibrium. The nucleus' active nature leads to many emergent properties of its principal components - the genome and the nucleoplasm - ranging from genome's compartmentalization, coherent chromatin motions, emergent rheology, to non-equilibrium liquid-liquid phase separations of the nucleoplasm. Its rich phenomenology makes the nucleus well-suited to bring new non-equilibrium physics to light, which in turn reveals its complex underlying physiology. Understanding the role of active processes in the spatial organization and dynamics of the genome and the nucleoplasm is critical for new insights into the function of the human genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.