ReviewAging2026
Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior.
Review in Aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With age, the incidence of stress-related pathologies, in the etiopathogenesis of which endocrine dysfunctions play an important role, increases. This review presents data on the study of age-related features in functioning of the key adaptive neuroendocrine axes (hypothalamic-pituitary-adrenal, HPA axis and hypothalamic-pituitary-thyroid, HPT axis) in individuals that differ in adaptive behavior with an emphasis on experimental studies in nonhuman primates. Studies have shown pronounced age-related differences in the functioning of HPA axis in the animals with depression-like and anxiety behavior (DAB): impairment negative feedback regulation with an increase of corticotropin and cortisol level in the afternoon - night time, a higher response to acute stress exposure, and sensitization of the hypothalamic-pituitary axis. A decrease secretion of thyroxine and its response to thyrotropin-releasing hormone (TRH) or thyrotropin administration with increased sensitivity of the adenohypophysis to TRH were identified in old DAB animals. In addition, older overweight DAB monkeys exhibited increased insulin resistance and reduced insulin and triglycerides secretion. Thus, age-related changes of HPA and HPT axes in DAB monkeys are associated with more pronounced endocrine dysfunctions as compared with young individuals, leading to hormonal imbalance that may contribute to the development of severe age-related pathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.