ReviewBiochemistry2026
The Ascent of Miniproteins.
Review in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Miniproteins are present across all branches of life and play central roles in diverse biological processes, but their existence fundamentally challenges our assumptions about the minimal sequence, structural, and energetic requirements necessary for protein stability and function. More than molecular curiosities, miniproteins may offer a window into the earliest catalysts that emerged at the origin of life. Here, we focus on metal-containing miniproteins, where coordination chemistry can impart both structural stability and redox activity essential for metabolism. We ask whether primordial peptides could have evolved into complex proteins through miniprotein intermediates by surveying natural miniproteins as snapshots along an evolutionary trajectory, and examining engineered miniproteins that can model the gaps between these snapshots. Finally, we explore whether miniproteins continue to evolve today─either recapitulating early evolutionary processes or giving rise to entirely new folds and functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.