ArticleScience (New York, N.Y.)2026
Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting.
Hao Fan, Zhong Zheng, Kaitlyn Oliphant, Jiacheng Li, Ryan Mack, Cheng-Wei Ju, Brandon Trandai, Jiayi Tu, Freya Q Zhang, Rukang Zhang and 19 more
Abstract read
In one paragraphArticle in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
29 authors.
Zhong Zheng *Department of Chemistry, The University of Chicago, Chicago, IL, USA.
Brandon TrandaiDepartment of Pediatrics, The University of Chicago, Chicago, IL, USA.
Chunzhao YinDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Lei DongQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9574-0148 Brian T LaydenDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Eugene B ChangDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Funding
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MLabeling and sequencing of 5hmC and 5mC in DNA-RenewalR01HG006827 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2012 to 2025
$7.2MMedical Scientist National Research Service AwardT32GM150375 · NIGMS · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2023 to 2026
$5.5MTyrosine Kinase Signaling in Cancer Cell MetabolismR01CA140515 · NCI · UNIVERSITY OF CHICAGO · PI Jing Chen · 2010 to 2026
$5.4MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MSignaling and Targeting of 6-Phosphogluconate Dehydrogenase in Human CancersR01CA174786 · NCI · UNIVERSITY OF CHICAGO · PI CHEN, JING · 2014 to 2024
$3.7MThe Gut Microbiome Brain Axis and Preterm InfantsR01HD105234 · NICHD · UNIVERSITY OF CHICAGO · PI CLAUD, ERIKA C · 2021 to 2025
$3.4MDietary trans-vaccenic acid enhances anti-tumor immunityR01CA276568 · NCI · UNIVERSITY OF CHICAGO · PI Jing Chen · 2023 to 2026
$1.5MDietary nutrient zeaxanthin enhances anti-tumor immunity by reprogramming CD8+ T cell functionF31CA290897 · NCI · UNIVERSITY OF CHICAGO · PI ZHANG, FREYA QI · 2025 to 2025
$22kHoward Hughes Medical InstituteNCI NIH HHS F31 CA290897NCI NIH HHS R01 CA140515NCI NIH HHS R01 CA174786NCI NIH HHS R01 CA276568NHGRI NIH HHS R01 HG006827NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NICHD NIH HHS R01 HD105234NIDA NIH HHS 75N95020D00005NIGMS NIH HHS T32 GM150375NIH HHS 75N93023D00005NIH HHS 75N99020D00005
6 · The paper itselfAbstract
How maternal nutrition influences neonatal immune development and imprinting through breastfeeding remains largely unclear. We report that maternal supplementation with trans-vaccenic acid (TVA), the predominant naturally occurring trans-fatty acid in human breast milk, promoted neonatal T cell development in mice. Neonates fed by mothers on a TVA-enriched diet showed an expanded naïve cluster of differentiation 4 (CD4
Indexed as
Adaptive ImmunityCD4-Positive T-LymphocytesMaternal Nutritional Physiological PhenomenaOleic AcidsTh1 CellsAnimalsAnimals, NewbornBreast FeedingDietary SupplementsFemaleHumansMiceMice, Inbred C57BLReceptors, G-Protein-CoupledT-bet Transcription FactorT-Box Domain Proteins11-octadecenoic acidOleic AcidsReceptors, G-Protein-CoupledT-bet Transcription FactorT-Box Domain Proteins
Identifiers
PMID42313977
PMCPMC13621437
What OpenQuestion holds
Textmetadata
Read underepoch 390