ArticleScience (New York, N.Y.)2026
CD4
Qiaoshi Lian, Jia Nie, Jatinder Singh, Qiang Chen, Jennifer Matta, Waipan Chan, Mariah Balmaceno-Criss, Melanie S Vacchio, Weiming Yu, Alexander D Clark and 4 more
Abstract read
In one paragraphArticle in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Qiaoshi Lian *Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3628-9390 Jia Nie *Laboratory of Immune Cell Biology and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Jatinder SinghSingle Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0006-7152-2131 Qiang ChenLaboratory of Immune Cell Biology and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0373-4459 Jennifer MattaMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0009-0006-4886-1987 Waipan ChanLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9109-6583 Mariah Balmaceno-CrissLaboratory of Immune Cell Biology and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5065-6062 Melanie S VacchioLaboratory of Immune Cell Biology and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5407-6439 Weiming YuLymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0004-8806-4398 Alexander D ClarkLaboratory of Immune Cell Biology and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Elijah EdmondsonMolecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-6106-3705 Michael C KellySingle Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0654-2778 Ronald N Germain *Lymphocyte Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-1495-9143 Rémy Bosselut *Laboratory of Immune Cell Biology and Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2033-1790 Funding
Genetic Analysis of T-cell DifferentiationZ01BC010671 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BOSSELUT, REMY · 2005 to 2008
$2.9MIntramural NIH HHS Z01 BC010671Intramural NIH HHS Z99 CA999999
6 · The paper itselfAbstract
Most cancer immunotherapy strategies are focused on direct tumor killing by immune cells, especially T lymphocytes. Clinical and conceptual limitations of these approaches create a need for additional strategies. We identified a tumor stroma-targeting mechanism in which tumor antigen-specific CD4
Indexed as
CD4-Positive T-LymphocytesImmunotherapyInterleukin-3NeoplasmsNeovascularization, PathologicTumor Necrosis Factor-alphaAnimalsAntigens, NeoplasmCell Line, TumorHumansLymphocyte ActivationMacrophagesMiceMice, Inbred C57BLMyeloid CellsAntigens, NeoplasmInterleukin-3Tumor Necrosis Factor-alpha
Identifiers
PMID42313973
PMCPMC13322214
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