Evidence map›Paper›PMID 42313933›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment.

Matasha Dhar, Edwin Vázquez-Rosa, Kalyani Chaubey, Emiko Miller, Sofia G Corella, Suwarna Chakraborty, Sunil Jamuna Tripathi, Tapatee Das, Xudong Liao, Mohamed Alkassem Alosman and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Matasha Dhar *Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-1714-0424
Edwin Vázquez-Rosa *Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0009-0005-4508-5217
Kalyani ChaubeyDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0002-6378-6739
Emiko MillerDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-3396-591X
Sofia G CorellaDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Suwarna ChakrabortyDepartment of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 44106.ORCID 0000-0001-9456-4322
Sunil Jamuna TripathiDepartment of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 44106.ORCID 0000-0001-9107-2437
Tapatee DasDepartment of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912.ORCID 0000-0002-5703-045X
Xudong LiaoDepartment of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912.
Mohamed Alkassem AlosmanDepartment of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912.ORCID 0000-0001-7872-7953
Hua FangDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Yeojung KohDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0002-4294-7871
Preethy S SridharanDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0001-7692-6342
Kathryn FrankeDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Coral J Cintrón-PérezDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Adrian A Cintrón-PérezDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Taylor TomcoDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Vidya IndrakumarDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0009-0005-6399-1459
Phoebe J RubinDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0009-0008-4877-4351
Justin G PieperDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Luke A AshikuDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.
Min-Kyoo ShinDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0001-6697-3639
Xinmiao TangYueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID 0000-0002-4864-8995
Roshan PadmanabhanTrailhead Biosystems Inc., Beechwood, OH 44122.
Hariprakash HaragopalDepartment of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272.
Margaret E FlanaganGlenn Bigg's Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78249.
Rajan JainDepartments of Medicine and Cell and Developmental Biology, Penn Cardiovascular Institute, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Bradley D WintersDepartment of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272.ORCID 0000-0002-0430-5405
Brigid M WilsonGeriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes VA Medical Center, Cleveland, OH 44106.ORCID 0000-0003-2966-2940
Bindu D PaulDepartment of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 44106.ORCID 0000-0002-1862-6103
Mukesh K JainDepartment of Molecular Biology, Cell Biology and Biochemistry, The Warren Alpert Medical School, Brown University, Providence, RI 02912.
Andrew A PieperDepartment of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0001-6299-6577

Funding

Deciphering how 3D genome organization orchestrates cardiac cellular identityR35HL166663 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rajan Jain · 2023 to 2026
$3.5M
NHLBI NIH HHS R35 HL166663
6 · The paper itself

Abstract

Deterioration of the blood-brain barrier (BBB), including impaired neurovascular uncoupling, contributes to cognitive decline in aging. The BBB is formed principally by brain microvascular endothelial cells (ECs), and ECs throughout the body are enriched for the transcription factor Krüppel-like factor 4 (KLF4). Because KLF4 levels in ECs decrease with age, we tested whether that decline contributes to aging-related BBB deterioration, neurovascular dysfunction, and cognitive impairment. Using EC-specific

Indexed as

AgingBlood-Brain BarrierEndothelial CellsKruppel-Like Transcription FactorsAnimalsBrainKruppel-Like Factor 4MaleMiceMice, KnockoutKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription Factorsagingblood–brain barrierendothelial cellKLF4neurodegeneration

Identifiers

PMID42313933
PMCPMC13291589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.