Evidence map›Paper›PMID 42313929›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

TL1A/DR3 signaling deletion attenuates mucosal inflammation and alveolar bone loss in a murine model of spontaneous periodontitis.

Sara Di Nicolantonio, Maria R Miranda, Adrian Gomez-Nguyen, Davide Pietropaoli, Annalisa Monaco, Paola Menghini, Fabio Cominelli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara Di NicolantonioDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Maria R MirandaDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0009-0005-8296-1888
Adrian Gomez-NguyenDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0000-0002-7226-6428
Davide PietropaoliDental Unit, Department of Clinical Medicine, Public Health, Life and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi, L'Aquila 67100, Italy.
Annalisa MonacoDental Unit, Department of Clinical Medicine, Public Health, Life and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi, L'Aquila 67100, Italy.
Paola Menghini *Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0000-0002-8779-088X
Fabio Cominelli *Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0000-0002-1571-1548

Funding

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK097948)
6 · The paper itself

Abstract

TL1A and its receptor DR3 are key regulators of mucosal immune responses, but their role in periodontal disease is unknown. Herein, we investigated whether TL1A/DR3 signaling contributes to mucosal immune amplification and tissue-destructive inflammation in periodontitis using SAMP1/YitFc (SAMP) mice, which develop spontaneous ileitis and periodontal disease. DR3 deficiency markedly attenuated alveolar bone loss and improved periodontal architecture, restoring a phenotype comparable to healthy AKR (parental) controls. Gingival tissues from wild-type SAMP mice exhibited increased expression of both

Indexed as

Alveolar Bone LossPeriodontitisReceptors, Tumor Necrosis Factor, Member 25Tumor Necrosis Factor Ligand Superfamily Member 15AnimalsCytokinesDisease Models, AnimalGingivaImmunity, MucosalInflammationMiceMice, KnockoutSignal TransductionCytokinesReceptors, Tumor Necrosis Factor, Member 25Tnfrsf25 protein, mouseTnfsf15 protein, mouseTumor Necrosis Factor Ligand Superfamily Member 15cytokinesIBDmucosal immunologyperiodontitis

Identifiers

PMID42313929
PMCPMC13291489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.