Evidence map›Paper›PMID 42313869›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Metal-Phenolic Coatings Enable Universal Design of Spherical Nucleic Acids.

Chaojian Chen, Taokun Luo, Ye Zhang, Xiaowei Liu, Hanwen Zhang, Chad A Mirkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chaojian ChenDepartment of Chemistry, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0002-2588-2447
Taokun LuoDepartment of Chemistry, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0001-5894-0490
Ye ZhangDepartment of Chemistry, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0001-5953-2173
Xiaowei LiuInternational Institute for Nanotechnology, Northwestern University, Evanston, Illinois, USA.ORCID 0009-0005-6334-3857
Hanwen ZhangInternational Institute for Nanotechnology, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0001-9030-4478
Chad A MirkinDepartment of Chemistry, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0002-6634-7627

Funding

Resource Development CoreU54DK137516 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Eun Ji Paige Chung, Pinelopi P. Kapitsinou · 2023 to 2026
$4.8M
Innovative Research for Cancer Nanotechnology (IRCN) for Enhancing Melanoma-specific Immune Responses by the Rational Design of Spherical Nucleic AcidsR01CA257926 · NCI · NORTHWESTERN UNIVERSITY · PI CHAD A. MIRKIN, Bin Zhang · 2022 to 2026
$2.5M
Spherical Nucleic Acid nano-architectures as first-in-class cGAS agonists for the immunotherapeutic treatment of Glioblastoma.R01CA275430 · NCI · WASHINGTON UNIVERSITY · PI MIRKIN, CHAD A., STEGH, ALEXANDER H. · 2022 to 2025
$2.3M
Air Force Office of Scientific Research FA9550-22-1-0300Bachrach Family FoundationChemistry for Life Processes InstituteDeutsche Forschungsgemeinschaft 453265186International Institute for NanotechnologyLefkofsky Family FoundationNational Cancer Institute of the National Institutes of Health R01CA257926National Cancer Institute of the National Institutes of Health R01CA275430NCI NIH HHS R01 CA257926NCI NIH HHS R01 CA275430NIDDK NIH HHS U54 DK137516Northwestern's MRSEC program NSF DMR-1720139NU Office for ResearchRobert H. Lurie Comprehensive Cancer CenterSoft and Hybrid Nanotechnology Experimental (SHyNE) Resource NSF ECCS-2025633State of Illinoisthe National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health U54DK137516
6 · The paper itself

Abstract

Spherical nucleic acids (SNAs), structures consisting of a nanoparticle core chemically modified with a dense shell of nucleic acids, are central to the fields of structural nanomedicine and colloidal crystal engineering with DNA. However, the synthetic methods used to prepare them often require different oligonucleotide immobilization chemistries for each type of core. Here, a general strategy to construct SNAs using metal-phenolic (MP) coatings is introduced. The polymeric shell formed through coordination bonds between polyphenols and metal ions (e.g., Fe

Indexed as

DNAGoldMetalsNucleic AcidsPhenolsSurface PropertiesDNAGoldMetalsNucleic AcidsPhenolscellular uptakeDNAmetal–phenolic networksself‐assemblyspherical nucleic acids

Identifiers

PMID42313869
PMCPMC13374119

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.