Evidence map›Paper›PMID 42313685›Full record

ArticleFetal diagnosis and therapy2026

Insights in Fetal Growth Trajectories of Spontaneous Twin Anemia Polycythemia Sequence Twins.

Margot J A van de Sande, Lisanne S A Tollenaar, Monique C Haak, Joanne E J T Verweij, Claar C M M Lap, Floor M M Prein, Enrico Lopriore, Femke Slaghekke

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Article in Fetal diagnosis and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Margot J A van de SandeDepartment of Obstetrics, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands, m.j.a.van_de_sande@lumc.nl.
Lisanne S A TollenaarDepartment of Obstetrics, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Monique C HaakDepartment of Obstetrics, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Joanne E J T VerweijDepartment of Obstetrics, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Claar C M M LapDepartment of Obstetrics, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Floor M M PreinDepartment of Obstetrics, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Enrico LoprioreDepartment of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands.
Femke SlaghekkeDepartment of Obstetrics, Division of Fetal Therapy, Leiden University Medical Center, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTwin anemia polycythemia sequence (TAPS) is a monochorionic twin condition, where imbalanced blood flow causes anemia in the donor twin and polycythemia in the recipient twin. While TAPS donors are frequently small for gestational age (SGA, birth weight <10th centile), fetal growth patterns are yet poorly understood.

methodsWe conducted a retrospective study of all spontaneous TAPS pregnancies diagnosed at Leiden University Medical Center between 2002 and 2024. Fetal growth was assessed by estimated fetal weight (EFW), with fetal growth restriction (FGR) defined as an EFW <10th centile. Secondary outcomes included SGA at birth and placental share distribution.

resultsA total of 45 consecutive spontaneous TAPS pregnancies were included. Donors consistently had lower EFW than recipients. At 20 weeks, FGR was present in 42% (5/12) of donors versus 0% (0/11) of recipients (p < 0.001). No recipients developed FGR before 24 weeks. By 30 weeks, FGR affected 55% (6/11) of donors and 9% (1/11) of recipients (p = 0.028). At birth, 58% (22/38) of donors had a larger placental share than their cotwin.

conclusionDespite a slightly larger placental share, TAPS donor twins are at higher risk of FGR. At birth, three out four TAPS donors are SGA compared to one out of five recipients.

Indexed as

Fetal growth patternFetal growth restrictionIntrauterine transfusionTwin anemia polycythemia sequence

Identifiers

PMID42313685
PMCPMC13446874

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