Trial reportTransfusion2026
Impact of platelet characteristics on post-transfusion count response in critically ill children on Extracorporeal Membrane Oxygenation: A secondary analysis of the ECSTATIC trial.
Trial report in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
15 authors.
Funding
Abstract
backgroundChildren supported by extracorporeal membrane oxygenation (ECMO) frequently receive platelet transfusions. However, little is known about how characteristics of platelet products affect transfusion effectiveness in ECMO patients. Our objective was to evaluate whether platelet product characteristics were associated with platelet count increment. STUDY DESIGN AND
methodsSecondary analysis of the ECSTATIC randomized controlled trial. Children <18 years on ECMO were randomized to two prophylactic platelet transfusion threshold strategies. In this secondary analysis, the exposure was platelet transfusions characterized by storage duration, ABO compatibility, platelet additive solution, irradiation, and pathogen reduction status. The primary outcome was the platelet count increment after transfusion, dichotomized as higher versus lower based on the median value. Regression models were used to identify associations between product characteristics and platelet count increment, adjusting for clustering.
resultsA total of 161 transfusions among 27 participants met inclusion criteria. The median change in platelet count was 19 × 10
conclusionsAmong critically ill children on ECMO, pathogen-reduction and pre-transfusion platelet count may influence the effectiveness of transfusion. These findings support the need for prospective trials that incorporate product-level characteristics into transfusion strategies for pediatric ECMO patients.
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