ArticleTheScientificWorldJournal2026
Integrated Phytochemical, Pharmacological, and In Silico Evaluation of the Methanolic Extract of Cayratia trifolia Leaves: Antioxidant, Anti-Inflammatory, and Analgesic Activities.
Article in TheScientificWorldJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
Cayratia trifolia is traditionally used for treating pain, inflammation, and oxidative disorders, yet comprehensive experimental and computational validation of its pharmacological potential remains limited. The aim of this study is to investigate the phytochemical profile and evaluate antioxidant, anti-inflammatory, and analgesic activities of methanolic and n-hexane fractions of C. trifolia leaves using integrated in vitro, in vivo, and in silico approaches. Leaves were extracted with methanol and fractionated via a modified Kupchan method. Phytochemical screening, DPPH radical scavenging, HRBC membrane stabilization, carrageenan-induced paw edema, acetic acid-induced writhing, and tail immersion assays were performed. In silico analysis included PASS prediction, ADME/T profiling, and molecular docking of 40 previously documented GC-MS compounds against COX-2 (PDB: 6COX, 1CX2, 5IKR, and 1CQE) and CYP2C9 (PDB: 1OG5 and 4L7B) protein targets. Methanolic extract demonstrated potent antioxidant activity (IC
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