Evidence map›Paper›PMID 42313311›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Fine-tuning alkyl chain length in copper(II) complexes: effects on DNA binding and catalytic cleavage.

Maiara I N Dos Santos, Matheus S S Paqui, Giliandro Farias, Edinara Luiz, Ronny R Ribeiro, Hernan Terenzi, Fernando R Xavier

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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maiara I N Dos Santos *Chemistry Department, Universidade do Estado de Santa Catarina (Udesc), Joinville, SC, Brazil.
Matheus S S Paqui *Chemistry Department, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Giliandro FariasDepartment of Materials Physics and Mechanics, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Edinara LuizChemistry Department, Universidade do Estado de Santa Catarina (Udesc), Joinville, SC, Brazil.
Ronny R RibeiroChemistry Department, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil.
Hernan TerenziChemistry Department, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil. hernan.terenzi@ufsc.br.
Fernando R XavierChemistry Department, Universidade do Estado de Santa Catarina (Udesc), Joinville, SC, Brazil. fernando.xavier@udesc.br.ORCID https://orcid.org/0000-0002-2056-4052

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Conselho Nacional de Desenvolvimento Científico e Tecnológico 306851/2022-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina 2025TR001442NCATS NIH HHS UL1 TR001442
6 · The paper itself

Abstract

Metal complexes are well known for their DNA cleavage activity. Copper is a metal that stands out for this purpose because it is able to perform cleavage through oxidative mechanisms using the Haber-Weiss cycle. We report two unprecedented copper(II) complexes (2 and 3) with long-chain ligands and compare the results with those of a previously reported complex (1), which we use as a reference in our studies. They were all properly characterized using a set of physicochemical methods, including elemental analysis, electron paramagnetic resonance, spectroscopic and electrochemical analysis. Density functional theory (DFT) modeling revealed a pseudo-octahedral environment where the ligands are trans to each other. The interaction of 1, 2, and 3 with salmon sperm DNA was monitored spectrophotometrically, and the binding constants (K

Indexed as

Coordination ComplexesCopperDNAAnimalsCatalysisDensity Functional TheoryDNA CleavageLigandsMolecular Docking SimulationMolecular StructureSalmonCoordination ComplexesCopperDNALigandsCopper(II) complexesDNA catalytic cleavageLong alkyl chain ligands

Identifiers

PMID42313311
PMCPMC13518454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.