ArticleMolecular biology reports2026
Comparative gut microbiota profiling of obese and normal-weight indian adults using 16S rRNA sequencing.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Integrated microbial and endocrine signatures of obesity:Frontiers in microbiomes · 2026Article
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5 authors.
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Abstract
backgroundObesity rates are rising globally, placing a significant strain on individuals, society, and economies. The gut microbiota (GM) plays a pivotal role in the development of obesity. Many studies have identified differences in GM composition between obese and normal-weight people worldwide. However, there is limited data on the GM profiles of obese and control Indian individuals.
methodsFecal samples from 20 participants (10 obese, 10 control) underwent 16 S rRNA gene sequencing. Anthropometric analysis confirmed significant differences in weight and BMI, with no significant variance in age or height. Taxonomic profiling and diversity indices (Chao1, Shannon, Simpson) were evaluated using the NCBI database.
resultsSequencing identified 1,359 Operational Taxonomic Units. The obese cohort exhibited an elevated Firmicutes-to-Bacteroidetes (F/B) ratio, with Firmicutes increasing to 53.78% and Bacteroidetes decreasing to 25.54%. A significant reduction in Fusobacteria was observed in the Ob group (p = 0.034). Seven species were nominally enriched in obese subjects: Bifidobacterium catenulatum (p = 0.031), Anaerostipes hadrus (p = 0.014), Eggerthella lenta(p = 0.032), Bifidobacterium bifidum (p = 0.037), Clostridium butyricum(p = 0.012), Phascolarctobacterium sp.(p = 0.046), and Alistipes onderdonkii(p = 0.033). Rarefaction curves showed higher species richness in the control group, whereas PCA plots indicated greater community similarity (lower beta diversity) in the obese group.
conclusionObesity is associated with distinct microbial dysbiosis, characterized by a significant loss of Fusobacteria and an enrichment of SCFA-producing species. These specific taxonomic shifts, rather than broad diversity indices, provide a more sensitive signature for metabolic changes associated with obesity, supporting the energy harvest hypothesis.
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