ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2026
High prevalence of molar-incisor hypomineralisation in sickle cell disease children and the association with haematologic profile: a retrospective cohort study.
Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study aimed to compare molar incisor hypomineralisation (MIH) prevalence and severity in children with sickle cell disease (SCD) versus healthy controls, whilst investigating associations with haematologic parameters and phenotypic disease expression.
methodsA retrospective cohort study included 60 SCD children (6-14 years) from a Brazilian haematology centre and 605 age-matched healthy controls, assessed between August 2022 and June 2023. Comprehensive dental examinations assessed MIH presence and severity. Laboratory investigations included complete blood count analysis (with erythroblast quantification) and phenotypic characterisation of SCD. Additional data collection encompassed dental anxiety, hypersensitivity, and aesthetic questionnaires for SCD participants. Statistical analysis employed chi-square, Mann-Whitney U, and Fisher's exact tests (α = 0.05).
resultsThe SCD group demonstrated significantly higher MIH prevalence compared to control (63.3% vs. 18.2%; p < 0.001) with a prevalence ratio of 3.48 (95% CI 2.66, 4.54). While severity distribution differed between groups (p < 0.001), severe MIH was less frequent in SCD (6/60 vs 32/605 controls; prevalence ratio = 1.72, 95% CI 1.05, 2.81; p = 0.03). MIH in SCD showed strong associations with the vaso-occlusive phenotype (86.8% of cases, p < 0.001) and reduced erythroblast counts (p = 0.014), but no significant correlations with demographic factors or reported dental symptoms.
conclusionChildren with SCD showed a significantly higher prevalence of MIH compared with healthy controls. In the SCD group, MIH was associated with the vaso-occlusive phenotype and lower erythroblast counts.
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