Evidence map›Paper›PMID 42313129›Full record

ArticlePediatric cardiology2026

Characteristics and Outcomes of Patients with Regression of Coronary Artery Aneurysms Caused by Kawasaki Disease.

Etsuko Tsuda, Akiyuki Kotoku, Yuki Ito

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Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Etsuko TsudaDepartment of Pediatric Cardiology, National Cerebral and Cardiovascular Center, 6-1Kishibeshinmachi, Suita, Osaka, 564-8565, Japan. etsukotsuda1@gmail.com.
Akiyuki KotokuDepartment of Radiology, National Cerebral and Cardiovascular Center, 6-1Kishibeshinmachi, Suita, Osaka, 564-8565, Japan.
Yuki ItoDepartment of Pediatric Cardiology, National Cerebral and Cardiovascular Center, 6-1Kishibeshinmachi, Suita, Osaka, 564-8565, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most medium to small-sized coronary artery aneurysms (CAAs) caused by Kawasaki disease (KD) can regress. To clarify the outcomes of patients with regressed-CAAs (r-CAAs). We reviewed characteristics and outcomes in 139 patients (male, 101; female, 38) with r-CAAs between 1978 and 2022 using medical records, including coronary angiograms and coronary computed tomography angiograms (CCTAs). The prevalence of localized stenosis (LS) and outcomes were calculated using the Kaplan-Meier method. Furthermore, the cut-off points of the maximum CAA diameter in the initial angiogram for coronary artery calcification (CAC) in late CCTAs were analyzed. The 25-year incidence of LS was 9.8% (95% CI, 3.6-23.8), and the 25-year cardiac event-free survival rate was 95.3% (95% CI 72.9-99.3). All LS cases were associated with CAC. Cut-off values of the initial maximum CAA diameter for CAC in branches and at bifurcations were 4.9 mm (n = 129, AUC 0.859, p < 0.0001) and 5.7 mm (n = 43, AUC 0.951, p = 0.0013), respectively. The corresponding Z scores were 6.75 (AUC 0.846, p < 0.0001) and 6.65 (AUC 0.921, p = 0.0014), respectively. The cut-off value of the interval time from the onset of KD to CAC detection was 10.0 years (AUC 0.673, p = 0.0053) in branches. LS with CAC in patients with r-CAAs can occur more than 10 years after the onset of KD. CAC after CAA regression is likely to appear at a maximum diameter of more than 5.0 mm (z score 6.7) in young adults; however, it may appear with aging in smaller r-CAAs.

Indexed as

Coronary artery aneurysmCoronary artery calcificationKawasaki diseaseLocalized stenosisRegression

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.