ArticleJACC. Case reports2026
Acute Pericarditis After Targeted Kinase Inhibitor Therapy in Acute Leukemia.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundFMS-like tyrosine kinase 3 (FLT3) inhibitors improve outcomes in acute myeloid leukemia cases but may cause cardiovascular toxicity. Inflammatory complications are rarely described. CASE SUMMARY: A 56-year-old man with FLT3-mutated acute myeloid leukemia developed acute pleuritic chest pain 3 days after the initiation of FLT3 inhibitor therapy. Electrocardiogram showed diffuse ST-segment elevation, and inflammatory markers were elevated (C-reactive protein 244 mg/L; normal <5 mg/L). Echocardiography revealed mild pericardial effusion. No viral prodrome or infectious cause was identified. Renal function and leukocyte count allowed standard therapy. The drug was discontinued, and treatment with ibuprofen and colchicine led to rapid resolution. DISCUSSION: FLT3 inhibitors have been associated with cardiotoxicity although pericardial inflammation is uncommon. This case supports a probable drug-related mechanism. TAKE-HOME MESSAGES: FLT3 inhibitors may cause acute pericarditis. Early recognition and drug withdrawal are essential for recovery.
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