Evidence map›Paper›PMID 42312835›Full record

ArticleMicrobiology spectrum2026

ClpC1-dependent iron homeostasis underlies mycobacterial defense against oxygen-driven Fenton reaction during reactivation.

Mingzhe Chi, Yuqing Zheng, Wenkai Zheng, Youran Chen, Bohong Zhou, Jiayu Chen, Jiacheng Bai, Yuchang Di, Xuelian Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingzhe ChiState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Yuqing ZhengState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Wenkai ZhengState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Youran ChenState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Bohong ZhouState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Jiayu ChenState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Jiacheng BaiState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Yuchang DiState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.
Xuelian ZhangState Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Institute of Infection and Health, Fudan University, Shanghai, China.ORCID 0000-0002-4999-3598

Funding

National Natural Science Foundation of China 82273974, 82574465
6 · The paper itself

Abstract

The caseinolytic protease (Clp) system, which is highly conserved and essential for protein homeostasis in mycobacteria, comprises the ClpP1P2 proteolytic core and the essential ATPases ClpC1 and ClpX. While ClpX has a defined role in DNA replication, and some differential substrates have been identified, the physiological functions distinguishing ClpC1 from ClpX remain incompletely understood. Here, using Clustered Regularly Interspaced Short Palindromic Repeats-mediated knockdown in

Indexed as

Bacterial ProteinsEndopeptidase ClpIronMycobacterium smegmatisMycobacterium tuberculosisOxygenAnimalsHomeostasisMiceOxidative StressReactive Oxygen SpeciesBacterial ProteinsEndopeptidase ClpIronOxygenReactive Oxygen SpeciesClp protease systemdrug targetsiron homeostasisMycobacteriumoxygen reactivation

Identifiers

PMID42312835
PMCPMC13435763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.