Sustained ppGpp production underpins months-long survival of a bacterium in growth arrest.

Elizabeth M Fones, Liang Yin, Dale Whittington, Caroline S Harwood

Abstract read

In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Genome-wide fitness profiling reveals flagellar rotation as an energetic liability during anaerobic maintenance inbioRxiv : the preprint server for biology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth M FonesDepartment of Microbiology, University of Washington, Seattle, Washington, USA.

Liang YinDepartment of Microbiology, University of Washington, Seattle, Washington, USA.

Dale WhittingtonDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington, USA.

Caroline S HarwoodDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-4450-5177

Funding

United States Army Research Office W911NF2110015

6 · The paper itself

Abstract

When growing bacteria start to reach stationary phase, the nucleotide guanosine tetra-phosphate (ppGpp) accumulates intracellularly and regulates the transition of cells from growth to growth arrest. Because commonly studied bacteria remain viable in stationary phase only briefly under laboratory conditions, the role of ppGpp in sustaining long-term bacterial survival after growth arrest has not been widely studied. IMPORTANCE: The molecular basis for long-term survival of starved bacteria is not well understood. The bacterium

Indexed as

Guanosine TetraphosphateMicrobial ViabilityRhodopseudomonasAdenosine TriphosphateGene Expression Regulation, BacterialGuanosine TriphosphateAdenosine TriphosphateGuanosine TetraphosphateGuanosine Triphosphatecellular survivalphototrophyppGppRhodopseudomonasstarvationstationary phasestringent response

Identifiers

PMID42312834

DOI10.1128/mbio.01079-26

PMCPMC13343836

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.