Evidence map›Paper›PMID 42312774›Full record

ArticleJACC. Advances2026

The Effect of Restrictive vs Liberal Blood Transfusion Strategy on Subsequent Myocardial Infarction Type.

Andrew P DeFilippis, J Dawn Abbott, Brandon M Herbert, Marnie H Bertolet, Bernard R Chaitman, Harvey D White, Andrew M Goldsweig, Tamar S Polonsky, Rajesh Gupta, Caroline Alsweiler and 14 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02981407 (Myocardial Ischemia and Transfusion), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02981407 phase3completednot on this map

Myocardial Ischemia and Transfusion

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2017 to 2023Enrolled3,506ConditionsMyocardial Infarction, AnemiaArmsRed Blood Cell Transfusion
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Andrew P DeFilippisDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address: andrew.defilippis@vumc.org.
J Dawn AbbottDivision of Cardiology, Brown University Health Cardiovascular Institute and Department of Medicine, Alpert Medical School of Warren Alpert Medical School, Providence, Rhode Island, USA.
Brandon M HerbertUniversity of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Marnie H BertoletUniversity of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Bernard R ChaitmanSt. Louis University School of Medicine, St. Louis, Missouri, USA.
Harvey D WhiteGreen Lane Coordinating Center, Auckland, New Zealand.
Andrew M GoldsweigBaystate Medical Center and Division of Cardiovascular Medicine, Department of Cardiovascular Medicine, University of Massachusetts-Baystate, Springfield, Massachusetts, USA.
Tamar S PolonskyDepartment of Medicine, University of Chicago Medicine, Chicago, Illinois, USA.
Rajesh GuptaDivision of Cardiovascular Medicine, Department of Medicine, University of Toledo, Toledo, Ohio, USA.
Caroline AlsweilerGreen Lane Coordinating Center, Auckland, New Zealand.
Johanne SilvainACTION Study Group, Sorbonne Université, INSERM UMRS1166, Institut de Cardiologie Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.
Pedro G M de Barros E SilvaBrazilian Clinical Research Institute, Sao Paulo, Brazil.
Graham S HillisDepartment of Cardiology, Royal Perth Hospital and Medical School, University of Western Australia, Perth, Australia.
Benoit DaneaultCentre hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
Meechai TessaleeDepartment of Medicine, University of Chicago Medicine, Chicago, Illinois, USA.
Mark A MenegusDivision of Cardiology, Montefiore Medical Center, New York, New York, USA.
Sunil V RaoNew York University Langone Health System, New York, New York, USA.
Renato D LopesBrazilian Clinical Research Institute, Sao Paulo, Brazil; Division of Cardiology, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA.
Paul C HébertBruyere Research Institute, University of Ottawa, Ottawa, Canada.
John H AlexanderDivision of Cardiology, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA.
Maria M BrooksUniversity of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Jeffrey L CarsonRutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Shaun G GoodmanSt. Michael's Hospital, Unity Health Toronto and Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Canada; Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada.
MINT Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData on the differential impact of interventions on subsequent myocardial infarction (MI) type are limited.

objectivesThis post-hoc analysis was done to evaluate the 30-day rate of subsequent MI by type (ie, type 1 and 2) among patients enrolled in the MINT (Myocardial Ischemia and Transfusion; NCT02981407) trial.

methodsSubdistribution HRs and cumulative incidences of subsequent MI types were computed using Fine-Gray subdistribution models that accounted for the competing risk of death and other MI types, if applicable. Effect modification of treatment strategy by index MI type was tested using log-binomial regression models.

resultsAmong 3,504 MINT trial patients, 275 (7.8%) had a 30-day subsequent MI, of which 118 (43%) were type 2 MI, 79 (28%) were uncertain MI type, 40 (15%) were type 4 MI, and 38 (14%) were type 1 MI. The rate of subsequent type 2 MI in patients randomized to the restrictive vs liberal transfusion was 3.5% (n = 61) vs 3.2% (n = 57) (HR: 1.07; 95% CI: 0.74-1.53) as compared with a subsequent type 1 MI rate of 1.3% (n = 23) vs 0.9% (n = 15) (HR: 1.53; 95% CI: 0.80-2.94).

conclusionsAmong patients with MI and anemia, subsequent MI occurred within 30 days in 7.8% of patients, with type 2 MI occurring 3 times more often than type 1 MI. A differential effect of the restrictive vs liberal transfusion strategy on the type of subsequent MI (eg, type 1 vs type 2) was not observed.

Indexed as

acute coronary syndromeblood transfusioncritical care cardiologymyocardial infarctiontype 1 myocardial infarctiontype 2 myocardial infarction

Identifiers

PMID42312774
PMCPMC13308243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.