Evidence map›Paper›PMID 42312561›Full record

ArticleJournal of surgical oncology2026

Prehabilitation Prior to Colorectal Cancer Surgery: Impact and Implementation.

Elize W Lockhorst, Theresia A M Backhuijs, Teun M E Kerkhoff, Robert R J Coebergh van den Braak, Ninos Ayez, Cornelis Verhoef, Paul D Gobardhan, Jennifer M J Schreinemakers

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Article in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elize W LockhorstDepartment of Surgery, Amphia Hospital Breda, Breda, The Netherlands.
Theresia A M BackhuijsDepartment of Sports Medicine, Amphia Hospital Breda, Breda, The Netherlands.
Teun M E KerkhoffDepartment of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Robert R J Coebergh van den BraakDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC University Cancer Institute, Rotterdam, The Netherlands.
Ninos AyezDepartment of Surgery, Amphia Hospital Breda, Breda, The Netherlands.
Cornelis VerhoefDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC University Cancer Institute, Rotterdam, The Netherlands.
Paul D GobardhanDepartment of Surgery, Amphia Hospital Breda, Breda, The Netherlands.
Jennifer M J SchreinemakersDepartment of Surgery, Amphia Hospital Breda, Breda, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMultimodal prehabilitation aims to improve surgical outcomes and preoperative fitness in patients undergoing surgery for colorectal cancer (CRC). This study evaluated implementation of a standardised prehabilitation programme for elective CRC surgery, assess its impact, and identify pitfalls and challenges during implementation.

methodsRetrospective single-centre study, all CRC patients scheduled for resection between January 2022 and April 2024 were included. Since May 2023, standardised multimodal prehabilitation was introduced. Before, patients received physiotherapy and a dietician if indicated, although this was not routinely offered. Patients were divided into a prehabilitation and non-prehabilitation group. Clinical data, prehabilitation details, and physiotherapy results were collected from patient charts.

resultsAmong 401 patients, 198 (49%) underwent prehabilitation. Participation increased after standardisation (40% vs. 59%, p < 0.001). Strength and physical fitness improved significantly (leg press 100 vs. 135 kg; steep ramp 160 vs. 213 W; p < 0.001). Patients in the non-standardised programme experienced a significantly longer postoperative hospital stay than those in standardised programme (4 vs. 3 days, p = 0.010). Despite more comorbidities in prehabilitated patients, complication rates were similar between patients without and with prehabilitation (28% vs. 24%, p = 0.45).

conclusionStandardised prehabilitation appears beneficial and safe, improving participation, referral justification and outcomes, particularly in high-risk colorectal cancer patients.

Indexed as

Colorectal NeoplasmsPreoperative CarePreoperative ExerciseAgedColorectal Surgical ProceduresFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective Studiescolorectal surgeryimplementationprehabilitationstandardised protocolsurgical outcomes

Identifiers

PMID42312561
PMCPMC13532825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.