ArticleSmall (Weinheim an der Bergstrasse, Germany)2026
Cascade-Activatable Nanoprobes for NIR-II Fluorescence/Photoacoustic Dual-Modal Imaging of Atherosclerotic Plaques.
Xiaowen He, Wanhuizi He, Xupeng Sun, Yuquan Ji, Likun Yin, Pu Xu, Wen Zhou, Hui Zhou, Chao Yin, Chen Xie and 1 more
Abstract read
In one paragraphArticle in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Xiaowen HeState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Wanhuizi HeState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Xupeng SunState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Yuquan JiState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Likun YinState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Pu XuState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Wen ZhouState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Hui ZhouState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.
Chao YinState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.ORCID 0000-0001-8211-2601 Chen XieState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.ORCID 0000-0002-1068-4691 Quli FanState Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, China.ORCID 0000-0002-9387-0165 Funding
Basic Research Program of Jiangsu BK20243057Jiangsu Provincial Postgraduate Research Innovation Program KYCX25_1185National Natural Science Foundation of China 22205115National Natural Science Foundation of China 22405132National Natural Science Foundation of China 52373142National Natural Science Foundation of China U24A2077Natural Science Foundation of Jiangsu Province BK20230060Natural Science Foundation of Jiangsu Province BK20240655
6 · The paper itselfAbstract
The rupture of atherosclerotic plaques is a crucial event leading to acute cardiovascular incidents like myocardial infarction and stroke, and accurate imaging of atherosclerotic plaques is of great significance. Currently, early and precise diagnosis of atherosclerosis (AS) is still a challenge because of the lack of suitable diagnostic methods and probes. Herein, we develop a novel cascade-activatable nanoprobe IR820-PDA@BSA-T, which can sequentially respond to AS-overexpressed protein disulfide isomerase (PDI) and high viscosity microenvironment, for second near-infrared window (NIR-II) fluorescence/photoacoustic imaging of AS. IR820-PDA@BSA-T was prepared by encapsulating a small-molecular dye IR820-PDA with bovine serum albumin (BSA), and then conjugating AS-targetable peptide VVGS onto its surface. Upon the activation of PDI, the NIR-II fluorescence intensity and ratiometric photoacoustic signal (PA
Indexed as
NanoparticlesPhotoacoustic TechniquesPlaque, AtheroscleroticAnimalsFluorescenceFluorescent DyesMiceSerum Albumin, BovineFluorescent DyesSerum Albumin, Bovineatherosclerosiscascade‐activatable probeNIR‐II fluorescence imagingphotoacoustic imaging
Identifiers
PMID42312552
PMCPMC13484983
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