Evidence map›Paper›PMID 42312436›Full record

ArticleJournal of medicinal chemistry2026

Dual-Acting Vitamin B

Beatriz L Pires-Lima, Sara C Silva-Reis, Xavier Cruz Correia, Hugo F Costa-Almeida, Vera M Costa, Xerardo García-Mera, José Brea, María I Loza, Marialessandra Contino, Maria Grazia Perrone and 4 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Beatriz L Pires-LimaLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-007, Portugal.ORCID 0000-0003-1464-7254
Sara C Silva-ReisLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-007, Portugal.ORCID 0000-0003-2024-0696
Xavier Cruz CorreiaLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-007, Portugal.ORCID 0000-0002-1440-9873
Hugo F Costa-AlmeidaLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-007, Portugal.ORCID 0000-0002-9034-2076
Vera M CostaUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Porto 4050-313, Portugal.ORCID 0000-0002-0471-2756
Xerardo García-MeraDepartment of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela E-15782, Spain.ORCID 0000-0001-5218-6351
José BreaInnopharma Screening Platform. Biofarma Research Group. Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela E-15782, Spain.ORCID 0000-0002-5523-1979
María I LozaInnopharma Screening Platform. Biofarma Research Group. Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela E-15782, Spain.ORCID 0000-0003-4730-0863
Marialessandra ContinoDepartment of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, Bari 70125, Italy.ORCID 0000-0002-0713-3151
Maria Grazia PerroneDepartment of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, Bari 70125, Italy.ORCID 0000-0003-4195-5228
Giovanni GrazianoDepartment of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, Bari 70125, Italy.ORCID 0000-0002-5575-3240
Nuno ValePerMed Research Group, RISE-Health, Faculty of Medicine, University of Porto, Porto 4200-319, Portugal.ORCID 0000-0002-1283-1042
José E Rodríguez-BorgesLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-007, Portugal.ORCID 0000-0002-9104-1670
Ivo E Sampaio-DiasLAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto 4169-007, Portugal.ORCID 0000-0002-9071-6197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) therapy remains limited by complications of the levodopa regimen, highlighting the need for novel therapeutic strategies to modulate dopaminergic signaling. Melanostatin (MIF-1) has attracted attention as a privileged scaffold for dopamine D

Indexed as

MSH Release-Inhibiting HormoneNeuroprotective AgentsNiacinReceptors, Dopamine D2AnimalsCell Line, TumorHumansStructure-Activity RelationshipMSH Release-Inhibiting HormoneNeuroprotective AgentsNiacinReceptors, Dopamine D2

Identifiers

PMID42312436
PMCPMC13370884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.