Coronary artery calcium and multiparametric cardiovascular risk assessment in non-dialysis chronic kidney disease.

Ivana Đuran, Nikola Komazec, Bojana Ljubičić, Ana Lazarević, Siniša Živković, Tijana Azaševac, Sonja Golubović, Mia Manojlović

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Biomolecules & biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ivana ĐuranFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Clinic of Nephrology and Clinical Immunology, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Nikola KomazecFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, Serbia.

Bojana LjubičićFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Department of Emergency Internal Medicine, Emergency Center, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Ana LazarevićFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Department of Emergency Internal Medicine, Emergency Center, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Siniša ŽivkovićFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Clinic of Nephrology and Clinical Immunology, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Tijana AzaševacFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Clinic of Nephrology and Clinical Immunology, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Sonja GolubovićFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Clinic of Nephrology and Clinical Immunology, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Mia ManojlovićFaculty of Medicine in Novi Sad, University of Novi Sad, Novi Sad, Serbia; Clinic for Endocrinology, Diabetes and Metabolic Disorders, University Clinical Center of Vojvodina, Novi Sad, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease is a leading cause of mortality in chronic kidney disease (CKD), but whether impaired renal function independently increases coronary artery calcium (CAC) burden in patients with comparable cardiovascular referral indications remains uncertain. This retrospective cross-sectional study included 206 adults who underwent coronary computed tomography angiography (CCTA) with simultaneous Agatston scoring at the Institute for Cardiovascular Diseases of Vojvodina between 2020 and 2025. Patients were classified as having eGFR-defined non-dialysis CKD stages 3-5 (n=110; estimated glomerular filtration rate [eGFR] ≤59 mL/min/1.73 m²) or preserved renal function (n=96; eGFR ≥60 mL/min/1.73 m²). Both groups were drawn from the same cardiovascular referral population. The primary outcome was total Agatston score, while secondary analyses included Agatston severity categories, significant vessel-level stenosis, calcified coronary segment count, eGFR-Agatston correlation, and predictors of severe CAC. Total Agatston scores did not differ significantly between CKD and control groups (median 248.5 vs. 198.0; p=0.240), and severe calcification was similarly frequent (40.0% vs. 41.6%). Vessel-level stenosis, calcified segment distribution, and the eGFR-Agatston correlation were also non-significant. In multivariable logistic regression adjusted for age, sex, hypertension, diabetes, and prior coronary artery bypass grafting (CABG), CKD was not independently associated with severe CAC. However, CKD patients showed a markedly more adverse cardiovascular phenotype, including more hypertension, angina, peripheral arterial disease, prior CABG, lower left ventricular ejection fraction (LVEF), higher right ventricular systolic pressure (RVSP), and more severe valvular disease. These findings suggest that CAC scoring alone does not capture the multidimensional cardiovascular burden of non-dialysis CKD and should be integrated with echocardiographic and systemic vascular assessment in high-risk referral populations.

Indexed as

CalciumCardiovascular DiseasesCoronary Artery DiseaseCoronary VesselsRenal Insufficiency, ChronicAgedComputed Tomography AngiographyCross-Sectional StudiesFemaleGlomerular Filtration RateHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsCalcium

Identifiers

PMID42312367

DOI10.17305/bb.2026.14105

PMCPMC13668002

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.