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Association Between Cannabis Use and Tinnitus: A Multi-Center Propensity-Score-Matched Cohort Study.
Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: There are mixed findings regarding the impact of cannabis use on tinnitus, with different patterns of cannabis use potentially influencing risk in varying ways. This study investigates the association between cannabis-related disorders (CRD) and the risk of developing tinnitus. Study Design: Propensity-score-matched cohort study. Setting: TriNetX, a multi-institutional research database. Methods: Adult patients (>18 years) with any CRD and no prior ear-related disorders were matched to a control group of patients without any history of CRD. Patients with CRD were stratified by increasing levels of cannabis use intensity based on the ICD-10 codes (use, abuse, or dependence). Propensity score matching controlled for demographic and related clinical variables, including migraine, nicotine and substance use, and mood disorders. The primary outcome was diagnosed tinnitus at 1, 5, and 10 years, analyzed using Cox regression hazard models (hazard ratios (HR), 95% confidence intervals). Results: After matching (n = 92,077 in each group), tinnitus incidence after 1, 5, and 10 years of CRD diagnosis was 0.7%, 1.8%, and 2.1%, respectively. One-year risk was significantly higher among those with any CRD (HR = 1.30, [95% CI: 1.16-1.45]). Compared to control at 1-year of follow-up, effect size was relatively higher among patients diagnosed with cannabis dependence (use: 1.30 [1.11-1.51]; abuse: 1.42 [1.05-1.90]; dependence: 1.55 [1.02-2.37]). There were no significant trends in tinnitus development at 5 and 10 years of follow-up with any CRD. Conclusion: Cannabis use may elevate the short-term risk of tinnitus, especially among those with more severe use. Further investigation should explore a potential dose-dependent relationship and underlying mechanisms.
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