Evidence map›Paper›PMID 42312240›Full record

ArticleOTO open

Late Recurrences Beyond Five Years in Salivary Adenoid Cystic Carcinoma: Implications for Long-Term Surveillance.

Prarthana J Dalal, Sarah M Dermody, Haadi Ali, Colin Brummel, J Chad Brenner, Marisa Buchakjian, Keith A Casper, Steven B Chinn, David Forner, Dena Hasan and 12 more

Abstract read
In one paragraph

Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Prarthana J DalalDepartment of Internal Medicine, Division of Hematology/Oncology University of Michigan Ann Arbor Michigan USA.
Sarah M DermodyDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Haadi AliDepartment of Internal Medicine, Division of Hematology/Oncology University of Michigan Ann Arbor Michigan USA.
Colin BrummelDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
J Chad BrennerDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Marisa BuchakjianDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Keith A CasperDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Steven B ChinnDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
David FornerDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Dena HasanDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Kelly M MalloyDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Jonathan McHughDepartment of Pathology University of Michigan Ann Arbor Michigan USA.
Michelle MierzwaDepartment of Radiation Oncology University of Michigan Ann Arbor Michigan USA.
Molly E Heft NealDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Mark E PrinceDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Jennifer ShahDepartment of Radiation Oncology University of Michigan Ann Arbor Michigan USA.
Andrew G ShumanDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Chaz L StuckenDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Matthew E SpectorDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Pratyusha YalamanchiDepartment of Otolaryngology University of Michigan Ann Arbor Michigan USA.
Francis P WordenDepartment of Internal Medicine, Division of Hematology/Oncology University of Michigan Ann Arbor Michigan USA.
Paul L SwiecickiDepartment of Internal Medicine, Division of Hematology/Oncology University of Michigan Ann Arbor Michigan USA.ORCID https://orcid.org/0000-0003-2286-3555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Salivary adenoid cystic carcinoma (ACC) is a rare head and neck malignancy with limited surveillance guidelines. ACC disease patterns are quite variable and unpredictable. Herein, we present an institutional retrospective review of salivary adenoid cystic carcinoma and discuss patterns and predictors of recurrence. Study Design: Retrospective cohort study. Setting: Single Quaternary Care Referral Center. Methods: We analyzed 102 adult patients with salivary gland adenoid cystic carcinoma between 1988 and 2019. Patient and tumor-related characteristics are summarized, and recurrence, survival, and metastatic site data are described. Results: Multivariable analysis showed that greater than 30% solid pathology was independently predictive of recurrence (HR 5.32, CI 2.23-12.66). Advanced stage disease (stages III and IV) was also predictive of recurrence (HR 3.77, CI 1.57-9.03). Nearly one-third of all patients experienced distant recurrence. Among patients experiencing distant recurrence, 29% were diagnosed with distant recurrence more than 5 years post-treatment. Conclusion: These data support long-term surveillance and clinical follow-up for patients with ACC.

Indexed as

adenoid cystic carcinomasalivary tumors

Identifiers

PMID42312240
PMCPMC13270494

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.