ArticleJournal of affective disorders reports2026
A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder.
J Douglas Bremner, Matthew T Wittbrodt, Nil Z Gurel, Jonathon A Nye, Mobashir H Shandhi, Asim H Gazi, Amit J Shah, Victoria Amorim, Bradley D Pearce, Viola Vaccarino and 1 more
Abstract read
In one paragraphArticle in Journal of affective disorders reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
J Douglas BremnerDepartment of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.ORCID 0000-0003-1633-6433 Matthew T WittbrodtDepartment of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Nil Z GurelSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta GA, United States.ORCID 0000-0002-3702-0449 Jonathon A NyeDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States.ORCID 0000-0002-4481-6031 Mobashir H ShandhiSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta GA, United States.
Asim H GaziSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta GA, United States.ORCID 0000-0003-4698-2823 Amit J ShahAtlanta VA Medical Center, Decatur, GA, United States.
Victoria AmorimDepartment of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States.ORCID 0009-0005-3095-1872 Bradley D PearceDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta GA, United States.
Viola VaccarinoDepartment of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta GA, United States.
Omer T InanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta GA, United States.
Funding
Non-Invasive Vagal Nerve Stimulation in Patients with Opioid Use DisordersUH3DA048502 · NIDA · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS, INAN, OMER TOLGA · 2023 to 2025
$5.8MNeural Circuits in Women with Abuse and PTSDR01MH056120 · NIMH · YALE UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 1999 to 2011
$5.0MDopamine function, inflammation and connectivity in PTSDR01MH120262 · NIMH · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2020 to 2023
$2.9MNon-Invasive Vagal Nerve Stimulation in Patients with Opioid Use Disorders UG3DA048502 · NIDA · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS, INAN, OMER TOLGA · 2020 to 2021
$844kShared Instrumentation for Research PET Brain DeviceS10RR016917 · NCRR · EMORY UNIVERSITY · PI BREMNER, JAMES DOUGLAS · 2002 to 2002
$500kCSRD VA I01 CX002331NCRR NIH HHS S10 RR016917NIDA NIH HHS UG3 DA048502NIDA NIH HHS UH3 DA048502NIMH NIH HHS R01 MH056120NIMH NIH HHS R01 MH120262RRD VA I01 RX003418
6 · The paper itselfAbstract
Objective: Posttraumatic Stress Disorder (PTSD) is a highly prevalent condition, and current treatments have limitations. Vagal Nerve Stimulation (VNS) is a new approach that potentially has promise for PTSD. Understanding the neurobiology of treatment response is important for developing new treatments. The purpose of this study was to assess neural correlations of long-term transcutaneous cervical VNS (tcVNS) in patients with PTSD. Methods: Patients with PTSD underwent randomization to active tcVNS ( Results: Three months of active tcVNS resulted in activation in response to traumatic scripts in the sham stimulation group not seen in the tcVNS group in brain areas mediating the fear response, including posterior cingulate, thalamus, temporal and parietal cortex, and parahippocampal gyrus, with an increase in medial prefrontal cortex with tcVNS, in patients with PTSD. Conclusion: TcVNS affects brain areas mediating fear and emotion which may underlie a therapeutic effect for PTSD.
Indexed as
Brain imagingNeuromodulation: Vagus nerve stimulationPosttraumaticPTSDStress disordersVagal nerve stimulationVagus nerve
Identifiers
PMID42312122
PMCPMC13271659
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